CK19 and OV6 Expressions in the Liver of 2-AAF/CCl4 Rat Model Article Swipe
Romy Arwinda
,
Isabella Kurnia Liem
,
Ayu Eka Fatril
,
Fanny Oktorina
,
Firda Asma’ul Husna
,
Ria Kodariah
,
Puspita Eka Wuyung
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3889/oamjms.2022.7923
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3889/oamjms.2022.7923
BACKGROUND: Liver regeneration on a chronic liver injury with rat model research is urgent to study the pathology of human chronic diseases. 2-Acetylaminofluorene (2-AAF) and Carbon Tetrachloride (CCl4) can be applied to study about liver regeneration by liver stem cells, known as oval cells. The use of 2-AAF and CCl4 (2-AAF/CCl4) to induce chronic liver injury can lead severe hepatocyte damages and extensive fibrosis. AIM: to observed the OV6 and CK19 expression in the liver of 2AAF/CCl4 rat model. METHODS: In this research, a high dose of 2-AAF (10mg/kg) was applied and combined repeatedly with CCl4 (2ml/kg) for 12 weeks. An immunohistochemistry (IHC) procedure by using OV6 and CK19 antibodies was also applied to examine the regeneration of oval cells. Both antibodies expressions were then examined semi-quantitatively according to the expressions percentage of each sample based on the liver zone. We have observed the OV6 and CK19 expressions in every zone, including in portae hepatis area. RESULTS: The results showed that OV6 and CK19 with the highest expression in the zone I. A significant difference between OV6 and CK19 expressions was revealed in healthy (control group) and 2-AAF/CCl4 groups (both indicating p=0.045). Moreover, a ductular reaction was also found in Zone I and II of the 2-AAF/CCl4. CONCLUSIONS: We conclude that 2-AAF/CCl4 induced chronic rat liver injury model, could be utilized to investigate the oval cells with OV6 and CK19 expression.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3889/oamjms.2022.7923
- https://oamjms.eu/index.php/mjms/article/download/7923/6980
- OA Status
- diamond
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4221137150
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4221137150Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3889/oamjms.2022.7923Digital Object Identifier
- Title
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CK19 and OV6 Expressions in the Liver of 2-AAF/CCl4 Rat ModelWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-30Full publication date if available
- Authors
-
Romy Arwinda, Isabella Kurnia Liem, Ayu Eka Fatril, Fanny Oktorina, Firda Asma’ul Husna, Ria Kodariah, Puspita Eka WuyungList of authors in order
- Landing page
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https://doi.org/10.3889/oamjms.2022.7923Publisher landing page
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https://oamjms.eu/index.php/mjms/article/download/7923/6980Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://oamjms.eu/index.php/mjms/article/download/7923/6980Direct OA link when available
- Concepts
-
CCL4, Medicine, Immunohistochemistry, Pathology, Carbon tetrachloride, Porta hepatis, Regeneration (biology), Liver injury, Liver regeneration, Hepatocyte, Internal medicine, Biology, Chemistry, Cell biology, In vitro, Organic chemistry, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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