Class 1 integrons and multiple mobile genetic elements in clinical isolates of the Klebsiella pneumoniae complex from a tertiary hospital in eastern China Article Swipe
Lan Wang
,
Mei Zhu
,
Chunxia Yan
,
Yanfang Zhang
,
Xuying He
,
Lin Wu
,
Jiefeng Xu
,
Junwan Lu
,
Qiyu Bao
,
Yunliang Hu
,
Teng Xu
,
Jialei Liang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2023.985102
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2023.985102
Background The emergence of highly drug-resistant K. pneumoniae , has become a major public health challenge. In this work, we aim to investigate the diversity of species and sequence types (STs) of clinical Klebsiella isolates and to characterize the prevalence and structure of class 1 integrons. Methods Based on the whole genome sequencing, species identification was performed by 16S rRNA gene homology and average nucleotide identity (ANI) analysis. STs were determined in accordance with the international MLST schemes for K. pneumoniae and K. variicola . Integron characterization and comparative genomic analysis were performed using various bioinformatic tools. Results Species identification showed that the 167 isolates belonged to four species: K. pneumoniae , K. variicola subsp. variicola , K. quasipneumoniae and K. aerogenes . Thirty-six known and 5 novel STs were identified in K. pneumoniae , and 10 novel STs were identified in K. variicola subsp. variicola . Class 1 integrons were found in 57.49% (96/167) of the isolates, and a total of 169 resistance gene cassettes encoding 19 types of resistance genes, including carbapenem resistance gene ( bla IPM-4 ) and class D β-lactamases gene ( bla OXA-1 and bla OXA-10 ), were identified. Among the 17 complete genomes, 29 class 1 integrons from 12 groups were found, only 1 group was encoded on chromosomes. Interestingly, one plasmid (pKP167-261) carrying two copies of approximately 19-kb IS 26 -Int1 complex resistance region that contains an integron and a multidrug resistance gene fragment. Conclusion The results of this work demonstrated that the species and STs of the clinical Klebsiella isolates were more complex by the whole genome sequence analysis than by the traditional laboratory methods. Finding of the new structure of MGEs related to the resistance genes indicates the great importance of deeply exploring the molecular mechanisms of bacterial multidrug resistance.
Related Topics
Concepts
Integron
Biology
Klebsiella pneumoniae
Genetics
Multilocus sequence typing
Gene
Microbiology
Plasmid
Genome
Multiple drug resistance
Klebsiella
Drug resistance
Escherichia coli
Genotype
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2023.985102
- https://www.frontiersin.org/articles/10.3389/fmicb.2023.985102/pdf
- OA Status
- gold
- Cited By
- 16
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4323313082
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4323313082Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2023.985102Digital Object Identifier
- Title
-
Class 1 integrons and multiple mobile genetic elements in clinical isolates of the Klebsiella pneumoniae complex from a tertiary hospital in eastern ChinaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-06Full publication date if available
- Authors
-
Lan Wang, Mei Zhu, Chunxia Yan, Yanfang Zhang, Xuying He, Lin Wu, Jiefeng Xu, Junwan Lu, Qiyu Bao, Yunliang Hu, Teng Xu, Jialei LiangList of authors in order
- Landing page
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https://doi.org/10.3389/fmicb.2023.985102Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmicb.2023.985102/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fmicb.2023.985102/pdfDirect OA link when available
- Concepts
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Integron, Biology, Klebsiella pneumoniae, Genetics, Multilocus sequence typing, Gene, Microbiology, Plasmid, Genome, Multiple drug resistance, Klebsiella, Drug resistance, Escherichia coli, GenotypeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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16Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 6, 2023: 4Per-year citation counts (last 5 years)
- References (count)
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63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.diversity | 24 |
| abstract_inverted_index.emergence | 2 |
| abstract_inverted_index.exploring | 291 |
| abstract_inverted_index.fragment. | 240 |
| abstract_inverted_index.including | 172 |
| abstract_inverted_index.indicates | 285 |
| abstract_inverted_index.integrons | 149, 202 |
| abstract_inverted_index.isolates, | 157 |
| abstract_inverted_index.molecular | 293 |
| abstract_inverted_index.multidrug | 237, 297 |
| abstract_inverted_index.performed | 56, 92 |
| abstract_inverted_index.structure | 41, 277 |
| abstract_inverted_index.variicola | 83, 113, 115, 143, 145 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Conclusion | 241 |
| abstract_inverted_index.Klebsiella | 33, 256 |
| abstract_inverted_index.Thirty-six | 123 |
| abstract_inverted_index.accordance | 72 |
| abstract_inverted_index.carbapenem | 173 |
| abstract_inverted_index.challenge. | 15 |
| abstract_inverted_index.determined | 70 |
| abstract_inverted_index.identified | 130, 140 |
| abstract_inverted_index.importance | 288 |
| abstract_inverted_index.integrons. | 45 |
| abstract_inverted_index.laboratory | 271 |
| abstract_inverted_index.mechanisms | 294 |
| abstract_inverted_index.nucleotide | 64 |
| abstract_inverted_index.pneumoniae | 7, 80, 110, 133 |
| abstract_inverted_index.prevalence | 39 |
| abstract_inverted_index.resistance | 163, 170, 174, 229, 238, 283 |
| abstract_inverted_index.comparative | 88 |
| abstract_inverted_index.identified. | 193 |
| abstract_inverted_index.investigate | 22 |
| abstract_inverted_index.resistance. | 298 |
| abstract_inverted_index.sequencing, | 52 |
| abstract_inverted_index.traditional | 270 |
| abstract_inverted_index.(pKP167-261) | 218 |
| abstract_inverted_index.characterize | 37 |
| abstract_inverted_index.chromosomes. | 214 |
| abstract_inverted_index.demonstrated | 247 |
| abstract_inverted_index.approximately | 223 |
| abstract_inverted_index.bioinformatic | 95 |
| abstract_inverted_index.international | 75 |
| abstract_inverted_index.β-lactamases | 183 |
| abstract_inverted_index.Interestingly, | 215 |
| abstract_inverted_index.drug-resistant | 5 |
| abstract_inverted_index.identification | 54, 99 |
| abstract_inverted_index.quasipneumoniae | 118 |
| abstract_inverted_index.characterization | 86 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5087585215, https://openalex.org/A5003791054 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I27781120, https://openalex.org/I4210099512, https://openalex.org/I4210127213, https://openalex.org/I4210152737 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.49000000953674316 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.85401388 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |