Classification of ossicular fixation based on a computational simulation of ossicular mobility Article Swipe
Sinyoung Lee
,
Hyeonsik You
,
Yoji MORITA
,
Sho Kanzaki
,
Fei Zhao
,
Takuji KOIKE
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-024-71474-4
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-024-71474-4
Ossicular fixation disturbs the mobility of the ossicular chain and causes conductive hearing loss. To diagnose the lesion area, otologists typically assess ossicular mobility through intraoperative palpation. Quantification of ossicular mobility and evidence-based diagnostic criteria are necessary for accurate assessment of each pathology, because diagnosis via palpation can rely on the surgeons' experiences and skills. In this study, ossicular mobilities were simulated in 92 pathological cases of ossicular fixation as compliances using a finite-element (FE) model of the human middle ear. The validity of the ossicular mobilities obtained from the FE model was verified by comparison with measurements of ossicular mobilities in cadavers using our newly developed intraoperative ossicular mobility measurement system. The fixation-induced changes in hearing were validated by comparison with changes in the stapedial velocities obtained from the FE model with measurements reported in patients and in temporal bones. The 92 cases were classified into four groups by conducting a cluster analysis based on the simulated ossicular compliances. Most importantly, the cases of combined fixation of the malleus and/or the incus with otosclerosis were classified into two different surgical procedure groups by degree of fixation, i.e., malleo-stapedotomy and stapedotomy. These results suggest that pathological characteristics can be detected using quantitatively measured ossicular compliances followed by cluster analysis, and therefore, an effective diagnosis of ossicular fixation is achievable.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-024-71474-4
- https://www.nature.com/articles/s41598-024-71474-4.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402193352
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402193352Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-024-71474-4Digital Object Identifier
- Title
-
Classification of ossicular fixation based on a computational simulation of ossicular mobilityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-03Full publication date if available
- Authors
-
Sinyoung Lee, Hyeonsik You, Yoji MORITA, Sho Kanzaki, Fei Zhao, Takuji KOIKEList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-024-71474-4Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41598-024-71474-4.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41598-024-71474-4.pdfDirect OA link when available
- Concepts
-
Malleus, Palpation, Otosclerosis, Fixation (population genetics), Incus, Medicine, Stapes, Middle ear, Surgery, Population, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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