Clinical and treatment outcomes of a second subcutaneous or intravenous anti-TNF in patients with ulcerative colitis treated with two consecutive anti-TNF agents: data from the ENEIDA registry Article Swipe

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Margalida Calafat , Paola Torres , Joan Toscá , Rubén Sánchez-Aldehuelo , Montserrat Rivero , Marisa Iborra , M González-Vivó , Isabel Vera , Luisa de Castro , Luís Bujanda , Manuel Barreiro‐de Acosta , Carlos González‐Muñoza , Xavier Calvet , J M Benítez , Mónica Llorente-Barrio , Gerard Surís , Fiorella Cañete , L Arias-García , David Monfort , Andrés Castaño‐García , Francisco Javier García‐Alonso , José María Huguet , Ignacio Marín‐Jiménez , Rufo Lorente , Albert Martín‐Cardona , Juan Ángel Ferrer , Patricia Camo , Javier P. Gisbert , Ramón Pajares , Fernando Gomollón , Jesús Castro‐Poceiro , Jair Morales-Alvarado , Jordina Llaó , A. Rodríguez Alonso , Cristina Rodríguez , Pablo Pérez-Galindo , Mercè Navarro , Nuria Jiménez-García , Marta Carrillo‐Palau , Isabel Blázquez-Gómez , Eva Sesé , Pedro Almela , Patricia Ramírez de la Piscina , Carlos Taxonera , Iago Rodríguez‐Lago , Lidia Cabrinety , M Vela , Miguel Mínguez , Francisco Mesonero , María José García , Mariam Aguas , Lucía Márquez , Marisol Silva Porto , Juan Ramón Pineda , Koldo García‐Etxebarria , Federico Bertoletti , Eduard Brunet , Míriam Mañosa , Eugeni Domènech ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1177/17562848231221713

Background: Infliximab seems to be the most efficacious of the three available anti-TNF agents for ulcerative colitis (UC) but little is known when it is used as the second anti-TNF. Objectives: To compare the clinical and treatment outcomes of a second subcutaneous or intravenous anti-TNF in UC patients. Design: Retrospective observational study. Methods: Patients from the ENEIDA registry treated consecutively with infliximab and a subcutaneous anti-TNF (or vice versa), naïve to other biological agents, were identified and grouped according to the administration route of the first anti-TNF into IVi (intravenous initially) or SCi (subcutaneous initially). Results: Overall, 473 UC patients were included (330 IVi and 143 SCi). Clinical response at week 14 was 42.7% and 48.3% in the IVi and SCi groups (non-statistically significant), respectively. Clinical remission rates at week 52 were 32.8% and 31.4% in the IVi and SCi groups (nonsignificant differences), respectively. A propensity-matched score analysis showed a higher clinical response rate at week 14 in the SCi group and higher treatment persistence in the IVi group. Regarding long-term outcomes, dose escalation and discontinuation due to the primary failure of the first anti-TNF and more severe disease activity at the beginning of the second anti-TNF were inversely associated with clinical remission. Conclusion: The use of a second anti-TNF for UC seems to be reasonable in terms of efficacy, although it is particularly reduced in the case of the primary failure of the first anti-TNF. Whether the second anti-TNF is infliximab or subcutaneous does not seem to affect efficacy.

Related Topics

Tumor Necrosis Factor Alpha

Inflammatory Bowel Disease

Disease

Concepts

Medicine Infliximab Discontinuation Ulcerative colitis Internal medicine TNF inhibitor Adalimumab Retrospective cohort study Tumor necrosis factor alpha Gastroenterology Inflammatory bowel disease Surgery Disease

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Type: article
Language: en
Landing Page: https://doi.org/10.1177/17562848231221713
PDF: https://journals.sagepub.com/doi/pdf/10.1177/17562848231221713
OA Status: gold
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Title: Clinical and treatment outcomes of a second subcutaneous or intravenous anti-TNF in patients with ulcerative colitis treated with two consecutive anti-TNF agents: data from the ENEIDA registry

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Language: en

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Publication year: 2024

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Publication date: 2024-01-01

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Authors: Margalida Calafat, Paola Torres, Joan Toscá, Rubén Sánchez-Aldehuelo, Montserrat Rivero, Marisa Iborra, M González-Vivó, Isabel Vera, Luisa de Castro, Luís Bujanda, Manuel Barreiro‐de Acosta, Carlos González‐Muñoza, Xavier Calvet, J M Benítez, Mónica Llorente-Barrio, Gerard Surís, Fiorella Cañete, L Arias-García, David Monfort, Andrés Castaño‐García, Francisco Javier García‐Alonso, José María Huguet, Ignacio Marín‐Jiménez, Rufo Lorente, Albert Martín‐Cardona, Juan Ángel Ferrer, Patricia Camo, Javier P. Gisbert, Ramón Pajares, Fernando Gomollón, Jesús Castro‐Poceiro, Jair Morales-Alvarado, Jordina Llaó, A. Rodríguez Alonso, Cristina Rodríguez, Pablo Pérez-Galindo, Mercè Navarro, Nuria Jiménez-García, Marta Carrillo‐Palau, Isabel Blázquez-Gómez, Eva Sesé, Pedro Almela, Patricia Ramírez de la Piscina, Carlos Taxonera, Iago Rodríguez‐Lago, Lidia Cabrinety, M Vela, Miguel Mínguez, Francisco Mesonero, María José García, Mariam Aguas, Lucía Márquez, Marisol Silva Porto, Juan Ramón Pineda, Koldo García‐Etxebarria, Federico Bertoletti, Eduard Brunet, Míriam Mañosa, Eugeni Domènech

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Concepts: Medicine, Infliximab, Discontinuation, Ulcerative colitis, Internal medicine, TNF inhibitor, Adalimumab, Retrospective cohort study, Tumor necrosis factor alpha, Gastroenterology, Inflammatory bowel disease, Surgery, Disease

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