Clinical Application of Radioembolization in Hepatic Malignancies: Protocol for a Prospective Multicenter Observational Study Article Swipe
Thomas Helmberger
,
Dirk Arnold
,
José Ignacio Bilbao
,
Niels de Jong
,
Geert Maleux
,
Anders Nordlund
,
Bora Peynırcıoğlu
,
Bruno Sangro
,
Ricky A. Sharma
,
Agnes Walk
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.2196/16296
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.2196/16296
Background Radioembolization, also known as transarterial radioembolization or selective internal radiation therapy with yttrium-90 (90Y) resin microspheres, is an established treatment modality for patients with primary and secondary liver tumors. However, large-scale prospective observational data on the application of this treatment in a real-life clinical setting is lacking. Objective The main objective is to collect data on the clinical application of radioembolization with 90Y resin microspheres to improve the understanding of the impact of this treatment modality in its routine practice setting. Methods Eligible patients are 18 years or older and receiving radioembolization for primary and secondary liver tumors as part of routine practice, as well as have signed informed consent. Data is collected at baseline, directly after treatment, and at every 3-month follow-up until 24 months or study exit. The primary objective of the Cardiovascular and Interventional Radiological Society of Europe Registry for SIR-Spheres Therapy (CIRT) is to observe the clinical application of radioembolization. Secondary objectives include safety, effectiveness in terms of overall survival, progression-free survival (PFS), liver-specific PFS, imaging response, and change in quality of life. Results Between January 2015 and December 2017, 1047 patients were included in the study. The 24-month follow-up period ended in December 2019. The first results are expected in the third quarter of 2020. Conclusions The CIRT is the largest observational study on radioembolization to date and will provide valuable insights to the clinical application of this treatment modality and its real-life outcomes. Trial Registration ClinicalTrials.gov NCT02305459; https://clinicaltrials.gov/ct2/show/NCT02305459 International Registered Report Identifier (IRRID) DERR1-10.2196/16296
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.2196/16296
- https://www.researchprotocols.org/2020/4/e16296/PDF
- OA Status
- gold
- Cited By
- 11
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3007619985
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3007619985Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2196/16296Digital Object Identifier
- Title
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Clinical Application of Radioembolization in Hepatic Malignancies: Protocol for a Prospective Multicenter Observational StudyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-02-21Full publication date if available
- Authors
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Thomas Helmberger, Dirk Arnold, José Ignacio Bilbao, Niels de Jong, Geert Maleux, Anders Nordlund, Bora Peynırcıoğlu, Bruno Sangro, Ricky A. Sharma, Agnes WalkList of authors in order
- Landing page
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https://doi.org/10.2196/16296Publisher landing page
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https://www.researchprotocols.org/2020/4/e16296/PDFDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.researchprotocols.org/2020/4/e16296/PDFDirect OA link when available
- Concepts
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Medicine, Observational study, Selective internal radiation therapy, Radiation therapy, Adverse effect, Clinical trial, Radiological weapon, Medical physics, Radiology, Internal medicine, Hepatocellular carcinomaTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2025: 2, 2024: 1, 2023: 3, 2022: 2, 2020: 2Per-year citation counts (last 5 years)
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33Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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