Clinical Characteristics and Risk Factors of Mortality Among Severe COVID-19 Patients Article Swipe

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Reham M. El-Morshedy , Maha Elkholy , Alaa Eldin Abdel-Moniem , Shimaa Abbas Hassan , Samiaa Hamdy Sadek ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.21203/rs.3.rs-166002/v1

Background:The novel corona virus is attacking several millions of people worldwide, resulting in death of almost a million and a half-humans. The rational of the current study was to detect clinical characteristics of severe COVID- 19 patients, and assessment of risk factors for death.Methodology:This retrospective cohort study included all laboratory confirmed COVID-19 patients with severe disease admitted to critical care unit in June and July 2020. All recorded data were collected,which included clinincal, radiological, and laboratory data, in addition to the outcome and duration of ICU stay.Statistical analysis was performed for obtaining descriptive information, comparison between living and dead patients,in addition to regression analysis to identify risk factors for mortality.Results:One hundred and three patients were included in the current study;cough and fever were the most common clinical presentations, and bilateral ground glass opacity was the most common radiological presentation. Patients had elevated values of neutrophils, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), serum ferritin, CRP, and D-dimer, also had longer ICU stay ,with reduced values of lymphocytes, and PaO₂/FIO₂ ratio. Most of these variables were more exaggerated in dead patients compared to living ones. Older age, lower values of PaO₂/FIO₂ ratio, and higher values of neutrophils, NLR, and D-dimer were predictors for death.Conclusion: Cough, fever and bilateral ground glass opacity were the most common clinical and radiological presentation of severe COVID 19. Older age, lower value of PaO₂/FIO₂ ratio, and higher values of D- dimer, neutrophil and NLR were risk factors associated with increased risk of mortality.

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Infectious Diseases (Medical Specialty)

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Coronavirus disease 2019 (COVID-19) 2019-20 coronavirus outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Medicine Intensive care medicine Internal medicine Virology Outbreak Disease Infectious disease (medical specialty)

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Type: preprint
Language: en
Landing Page: https://doi.org/10.21203/rs.3.rs-166002/v1
PDF: https://www.researchsquare.com/article/rs-166002/latest.pdf
OA Status: gold
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DOI: https://doi.org/10.21203/rs.3.rs-166002/v1

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Title: Clinical Characteristics and Risk Factors of Mortality Among Severe COVID-19 Patients

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Language: en

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Publication year: 2021

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Publication date: 2021-02-08

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Authors: Reham M. El-Morshedy, Maha Elkholy, Alaa Eldin Abdel-Moniem, Shimaa Abbas Hassan, Samiaa Hamdy Sadek

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Landing page: https://doi.org/10.21203/rs.3.rs-166002/v1

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Concepts: Coronavirus disease 2019 (COVID-19), 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Medicine, Intensive care medicine, Internal medicine, Virology, Outbreak, Disease, Infectious disease (medical specialty)

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abstract_inverted_index.radiological,	74
abstract_inverted_index.retrospective	45
abstract_inverted_index.presentations,	128
abstract_inverted_index.characteristics	32
abstract_inverted_index.collected,which	71
abstract_inverted_index.stay.Statistical	87
abstract_inverted_index.<title>Abstract</title>	0
abstract_inverted_index.<bold>Background:</bold>The	1
abstract_inverted_index.death.<bold>Conclusion:</bold>	204
abstract_inverted_index.PaO<sub>2</sub>/FIO<sub>2</sub>	170, 191, 229
abstract_inverted_index.mortality.<bold>Results:</bold>One	110
abstract_inverted_index.death.<bold>Methodology:</bold>This	44
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sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
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sustainable_development_goals[0].display_name	Good health and well-being
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