Clinical, Cognitive and Behavioural Assessment in Children with Cerebellar Disorder Article Swipe
Stefano D’Arrigo
,
Carmela Loiacono
,
Claudia Ciaccio
,
Chiara Pantaleoni
,
Flavia Faccio
,
Matilde Taddei
,
Sara Bulgheroni
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/app11020544
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/app11020544
Cerebellar disorders are characterised clinically by specific signs and symptoms, often associated with neurodevelopmental disorder. While the clinical signs of cerebellar disorders are clearly recognisable in adults and have a precise anatomo-functional correlation, in children the semiotics are less clear and vary with age because of the particular nature of the cerebellum’s maturation. Unlike other structures of the central nervous system, this begins at a later stage of foetal development and extends over a longer period of time, even after birth. As a result, the typical signs of cerebellar dysfunction will only become evident when the cerebellar functions have become integrated into the complex circuits of the central nervous system. This means that poor motor coordination in the very early years of life may not necessarily correlate with cerebellar dysfunction, and this may also be encountered in healthy children. The cerebellum’s role in cognitive and emotional functions relies on its structure and the complexity of its connections. Cognitive and behavioral impairment in cerebellar disorders can be the results of acquired lesions or the action of genetic and environmental risk factors, to which the cerebellum is particularly vulnerable considering its pattern of development. In the pathological setting, early evidence of cerebellar damage may be very vague, due, partly, to spontaneous compensation phenomena and the vicarious role of the connecting structures (an expression of the brain’s plasticity). Careful clinical assessment will nonetheless enable appropriate instrumental procedures to be arranged. It is common knowledge that the contribution of neuroimaging is crucial for diagnosis of cerebellar conditions, and neurophysiological investigations can also have a significant role. The ultimate goal of clinicians is to combine clinical data and instrumental findings to formulate a precise diagnostic hypothesis, and thus request a specific genetic test in order to confirm their findings, wherever possible.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/app11020544
- https://www.mdpi.com/2076-3417/11/2/544/pdf?version=1610092262
- OA Status
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3119248321Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/app11020544Digital Object Identifier
- Title
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Clinical, Cognitive and Behavioural Assessment in Children with Cerebellar DisorderWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-08Full publication date if available
- Authors
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Stefano D’Arrigo, Carmela Loiacono, Claudia Ciaccio, Chiara Pantaleoni, Flavia Faccio, Matilde Taddei, Sara BulgheroniList of authors in order
- Landing page
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https://doi.org/10.3390/app11020544Publisher landing page
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https://www.mdpi.com/2076-3417/11/2/544/pdf?version=1610092262Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-3417/11/2/544/pdf?version=1610092262Direct OA link when available
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Cerebellum, Neuroscience, Neuroimaging, Psychology, Cognition, Pathological, Medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 1, 2024: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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