Clinical efficacy of different irrigation protocols in teeth with chronic apical periodontitis: Randomized clinical trial - a pilot study Article Swipe
Katarina Ivezic
,
Boško Toljić
,
Katarina Beljic-Ivanovic
,
Aleksandar Jakovljević
,
Biljana Miličić
,
Ema Krdžović Lazić
,
Ivan Arsić
,
Nenad Nedeljković
,
Milan Drobac
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2298/sarh250622054i
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2298/sarh250622054i
Introduction/Objective. Effective disinfection of the root canal system is essential for successful endodontic treatment. This study aimed to determine the most effective final irrigation protocol. Methods. This randomized clinical trial investigated the antimicrobial efficacy of three irrigation protocols in 30 patients with asymptomatic apical periodontitis in single-rooted teeth. The groups were: (1) 2.5% sodium hypochlorite (NaOCl) + 17% ethylenediaminetetraacetic acid (EDTA); (2) NaOCl + EDTA + 2% chlorhexidine (CHX); and (3) the same as Group 2 with sonic agitation (EndoActivator). Microbial samples were collected at three intervals and analyzed using endpoint and real-time PCR targeting seven key endodontic pathogens. Results. Group 3 demonstrated the greatest bacterial reduction across all time points, with CHX-containing protocols significantly outperforming NaOCl + EDTA alone. Sonic activation further enhanced irrigant efficacy, notably reducing P. gingivalis. Despite improvements, complete bacterial eradication was not achieved, and E. faecalis and F. nucleatum remained persistent. Conclusion. While limitations in microbial sampling and profiling exist, the results underscore the importance of combining chemical agents and mechanical activation to manage complex root canal infections effectively.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2298/sarh250622054i
- http://www.doiserbia.nb.rs/ft.aspx?id=0370-81792500054I
- OA Status
- diamond
- References
- 30
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4412476835Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2298/sarh250622054iDigital Object Identifier
- Title
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Clinical efficacy of different irrigation protocols in teeth with chronic apical periodontitis: Randomized clinical trial - a pilot studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-01Full publication date if available
- Authors
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Katarina Ivezic, Boško Toljić, Katarina Beljic-Ivanovic, Aleksandar Jakovljević, Biljana Miličić, Ema Krdžović Lazić, Ivan Arsić, Nenad Nedeljković, Milan DrobacList of authors in order
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https://doi.org/10.2298/sarh250622054iPublisher landing page
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https://www.doiserbia.nb.rs/ft.aspx?id=0370-81792500054IDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.doiserbia.nb.rs/ft.aspx?id=0370-81792500054IDirect OA link when available
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Medicine, Dentistry, Periodontitis, Randomized controlled trial, Chronic periodontitis, Clinical trial, Orthodontics, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.(EndoActivator). | 79 |
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