Clinical Efficacy of Ovine Forestomach Matrix and Collagen/Oxidised Regenerated Cellulose for the Treatment of Venous Leg Ulcers: A Retrospective Comparative Real‐World Evidence Study Article Swipe
Rebecca Aburn
,
Abigail E. Chaffin
,
Brandon A. Bosque
,
Christopher Frampton
,
Sandi G. Dempsey
,
D. Adam Young
,
Barnaby C. H. May
,
Gregory Bohn
,
M. Mark Melin
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/iwj.70368
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/iwj.70368
Venous leg ulcers (VLUs) are traditionally managed with standard‐of‐care dressings, compression and appropriate adjunctive venous interventions for pathologic venous reflux. Due to pathophysiological complexity and underlying patient comorbidities, conducting randomised controlled trials to evaluate the comparative efficacy of advanced treatment modalities is difficult, as many patients would likely be excluded. This retrospective, pragmatic, real‐world evidence (RWE) study compared the healing outcomes of VLUs treated with either ovine forestomach matrix (OFM) ( n = 312) or collagen/oxidised regenerated cellulose (ORC) ( n = 239) in outpatient wound care centres. Unlike restrictive randomised controlled trials, minimal inclusion and exclusion criteria were applied to create two treatment cohorts that reflected the general VLU population. The incidence (%) of closure was greater in OFM‐treated VLUs at 12, 24 and 36 weeks, and this difference was significant at 24 and 36 weeks compared to collagen/ORC. Median time to wound closure was significantly faster ( p = 0.045) in the OFM cohort (11.1 ± 0.6 weeks) compared to the collagen/ORC group (12.3 ± 1.0 weeks). Cox proportional hazards analysis demonstrated that OFM‐treated VLUs had a significantly greater probability of healing (up to ~40%). This RWE comparative efficacy study further substantiates the clinical benefit of OFM in the treatment of chronic wounds, such as VLU, in a real‐world patient cohort.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/iwj.70368
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iwj.70368
- OA Status
- gold
- Cited By
- 3
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409589381
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4409589381Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/iwj.70368Digital Object Identifier
- Title
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Clinical Efficacy of Ovine Forestomach Matrix and Collagen/Oxidised Regenerated Cellulose for the Treatment of Venous Leg Ulcers: A Retrospective Comparative Real‐World Evidence StudyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-04-01Full publication date if available
- Authors
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Rebecca Aburn, Abigail E. Chaffin, Brandon A. Bosque, Christopher Frampton, Sandi G. Dempsey, D. Adam Young, Barnaby C. H. May, Gregory Bohn, M. Mark MelinList of authors in order
- Landing page
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https://doi.org/10.1111/iwj.70368Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iwj.70368Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iwj.70368Direct OA link when available
- Concepts
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Medicine, Cohort, Retrospective cohort study, Refractory (planetary science), Clinical trial, Cohort study, Randomized controlled trial, Surgery, Internal medicine, Physics, AstrobiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
- References (count)
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64Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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