Clinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non–Small-Cell Lung Cancer and Brain Metastases Article Swipe
Daniel B. Costa
,
Alice T. Shaw
,
Sai‐Hong Ignatius Ou
,
Benjamin Solomon
,
Gregory J. Riely
,
Myung‐Ju Ahn
,
Caicun Zhou
,
S. Martin Shreeve
,
Paulina Selaru
,
Anna Polli
,
Patrick Schnell
,
Keith D. Wilner
,
Robin Wiltshire
,
D. Ross Camidge
,
Lucio Crinò
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1200/jco.2014.59.0539
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1200/jco.2014.59.0539
Purpose Crizotinib is an oral kinase inhibitor approved for the treatment of ALK-rearranged non–small-cell lung cancer (NSCLC). The clinical benefits of crizotinib in patients with brain metastases have not been previously studied. Patients and Methods Patients with advanced ALK-rearranged NSCLC enrolled onto clinical trial PROFILE 1005 or 1007 (randomly assigned to crizotinib) were included in this retrospective analysis. Patients with asymptomatic brain metastases (nontarget or target lesions) were allowed to enroll. Tumor assessments were evaluated every 6 weeks using RECIST (version 1.1). Results At baseline, 31% of patients (275 of 888) had asymptomatic brain metastases; 109 had received no prior and 166 had received prior brain radiotherapy as treatment. Among patients with previously untreated asymptomatic brain metastases, the systemic disease control rate (DCR) at 12 weeks was 63% (95% CI, 54% to 72%), the intracranial DCR was 56% (95% CI, 46% to 66%), and the median intracranial time to progression (TTP) was 7 months (95% CI, 6.7 to 16.4). Among patients with previously treated brain metastases, the systemic DCR was 65% (95% CI, 57% to 72%), the intracranial DCR was 62% (95% CI, 54% to 70%), and the median intracranial TTP was 13.2 months (95% CI, 9.9 to not reached). Patients with systemic disease control were also likely to experience intracranial disease control at 12 weeks (correlation coefficient, 0.7652; P < .001). Among patients without baseline brain metastases who developed progressive disease (n = 253) after initiation of crizotinib, 20% were diagnosed with brain metastases. Conclusion Crizotinib was associated with systemic and intracranial disease control in patients with ALK-rearranged NSCLC who were ALK inhibitor naive and had brain metastases. However, progression of preexisting or development of new intracranial lesions while receiving therapy was a common manifestation of acquired resistance to crizotinib.
Related Topics
Concepts
Crizotinib
Medicine
Asymptomatic
Brain metastasis
Lung cancer
Internal medicine
ALK inhibitor
Oncology
Anaplastic lymphoma kinase
Brain tumor
Cancer
Surgery
Gastroenterology
Metastasis
Pathology
Malignant pleural effusion
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1200/jco.2014.59.0539
- OA Status
- green
- Cited By
- 598
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2151116840
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2151116840Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1200/jco.2014.59.0539Digital Object Identifier
- Title
-
Clinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non–Small-Cell Lung Cancer and Brain MetastasesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-01-27Full publication date if available
- Authors
-
Daniel B. Costa, Alice T. Shaw, Sai‐Hong Ignatius Ou, Benjamin Solomon, Gregory J. Riely, Myung‐Ju Ahn, Caicun Zhou, S. Martin Shreeve, Paulina Selaru, Anna Polli, Patrick Schnell, Keith D. Wilner, Robin Wiltshire, D. Ross Camidge, Lucio CrinòList of authors in order
- Landing page
-
https://doi.org/10.1200/jco.2014.59.0539Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/4451171Direct OA link when available
- Concepts
-
Crizotinib, Medicine, Asymptomatic, Brain metastasis, Lung cancer, Internal medicine, ALK inhibitor, Oncology, Anaplastic lymphoma kinase, Brain tumor, Cancer, Surgery, Gastroenterology, Metastasis, Pathology, Malignant pleural effusionTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
598Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 12, 2024: 24, 2023: 29, 2022: 50, 2021: 45Per-year citation counts (last 5 years)
- References (count)
-
40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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