Clinical Features and Outcomes of Very‐Early‐Onset Inflammatory Bowel Disease in Brazilian Children Article Swipe
Debora Avellaneda Penatti
,
Nilton Carlos Machado
,
Mary de Assis Carvalho
,
Maria Aparecida Marchesan Rodrigues
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1097/pg9.0000000000000032
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1097/pg9.0000000000000032
We report on 20 Brazilian children under 6 years of age with very‐early‐onset inflammatory bowel disease naive to treatment. The clinical, laboratory, and histopathologic findings at diagnosis and outcomes were reviewed: 13 had ulcerative colitis (UC) and 7 had Crohn disease (CD). The final diagnostic pattern was as follows: 4 children had neonatal‐onset (1 UC and 3 CD), 8 had infantile subtype (4 UC and 4 CD), and 8 had UC beyond the neonatal and infantile period. Both forms of inflammatory bowel disease were severe and extensive at diagnosis, with a high prevalence of bloody diarrhea, reflecting the colonic location of the disease. UC was predominantly pancolonic, CD was isolated in the colon and associated with perianal disease. Children with CD were younger than those with UC, were significantly more nutritionally impaired, and had more complications. This study shows that very‐early‐onset inflammatory bowel disease has an aggressive clinical course with 2 distinct phenotypes, UC and CD, with differences in severity, clinical behavior, and inflammatory pattern but with a preponderance of colonic involvement in both types.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/pg9.0000000000000032
- OA Status
- hybrid
- References
- 17
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3114993603Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/pg9.0000000000000032Digital Object Identifier
- Title
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Clinical Features and Outcomes of Very‐Early‐Onset Inflammatory Bowel Disease in Brazilian ChildrenWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2020Year of publication
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2020-12-22Full publication date if available
- Authors
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Debora Avellaneda Penatti, Nilton Carlos Machado, Mary de Assis Carvalho, Maria Aparecida Marchesan RodriguesList of authors in order
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https://doi.org/10.1097/pg9.0000000000000032Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1097/pg9.0000000000000032Direct OA link when available
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Medicine, Ulcerative colitis, Inflammatory bowel disease, Disease, Age of onset, Clinical phenotype, Diarrhea, Bloody diarrhea, Gastroenterology, Bloody, Internal medicine, Crohn's disease, Colitis, Phenotype, Surgery, Gene, Chemistry, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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17Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2020-12-22 |
| publication_year | 2020 |
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