Clinical Performance of SARS-CoV-2 Molecular Testing Article Swipe
Daniel A. Green
,
Jason Zucker
,
Lars F. Westblade
,
Susan Whittier
,
Hanna Rennert
,
Priya Velu
,
Arryn Craney
,
Melissa M. Cushing
,
Dakai Liu
,
Magdalena E. Sobieszczyk
,
Amelia K. Boehme
,
Jorge L. Sepulveda
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.06.20093575
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.06.20093575
Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the gold standard for diagnosis of coronavirus disease 2019 (COVID-19), but the test clinical performance is poorly understood. From 3/10/2020-5/1/2020 NewYork-Presbyterian laboratories performed 27,377 SARS-CoV-2 molecular assays from 22,338 patients. Repeat testing was performed in 3,432 patients, of which 2,413 had negative and 1,019 had positive first day results. Repeat-tested patients were more likely to be older, male, African-American or Hispanic, and to have severe disease. Among the patients with initially negative results, 18.6% became positive upon repeat-testing. Only 58.1% of any-time positive patients had a result of “detected” on the first test. The clinical sensitivity of COVID-19 molecular assays is estimated between 66.2 % and 95.6%, depending on the unknown number of false negative results in single-tested patients. Conversion to a negative result is unlikely to occur before 15 to 20 days after initial testing or 20-30 days after the onset of symptoms, with 50% conversion occurring at 28 days after initial testing. Forty-nine initially-positive patients converted to negative and then back to positive in subsequent days. Conversion from first day negative to positive results increased linearly with each day of testing, reaching 25% probability in 20 days. In summary, our study provides estimates of the clinical performance of SARS-CoV-2 molecular assays and suggests time frames for appropriate repeat testing, namely 15 to 20 days after a positive test and the same or next 2 days after a negative test in a patient with high suspicion for COVID-19.
Related Topics
Concepts
Medicine
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Coronavirus disease 2019 (COVID-19)
Gold standard (test)
False Negative Reactions
Internal medicine
Coronavirus
Disease
Diagnostic test
Gastroenterology
Pediatrics
Infectious disease (medical specialty)
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.05.06.20093575
- https://www.medrxiv.org/content/medrxiv/early/2020/05/08/2020.05.06.20093575.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3034809701
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3034809701Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.05.06.20093575Digital Object Identifier
- Title
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Clinical Performance of SARS-CoV-2 Molecular TestingWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-05-08Full publication date if available
- Authors
-
Daniel A. Green, Jason Zucker, Lars F. Westblade, Susan Whittier, Hanna Rennert, Priya Velu, Arryn Craney, Melissa M. Cushing, Dakai Liu, Magdalena E. Sobieszczyk, Amelia K. Boehme, Jorge L. SepulvedaList of authors in order
- Landing page
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https://doi.org/10.1101/2020.05.06.20093575Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2020/05/08/2020.05.06.20093575.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2020/05/08/2020.05.06.20093575.full.pdfDirect OA link when available
- Concepts
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Medicine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), Gold standard (test), False Negative Reactions, Internal medicine, Coronavirus, Disease, Diagnostic test, Gastroenterology, Pediatrics, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2020: 2Per-year citation counts (last 5 years)
- References (count)
-
18Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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