Clinical Practice Recommendations on the Role Of Allogeneic Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T-Cell Therapy in Patients With Chronic Lymphocytic Leukemia on Behalf of the American Society for Transplantation and Cellular Therapy Article Swipe
Mohamed A. Kharfan‐Dabaja
,
Ambuj Kumar
,
Javier Pinilla‐Ibarz
,
Jennifer R. Brown
,
Mazyar Shadman
,
Farrukh T. Awan
,
Saad S. Kenderian
,
Tanya Siddiqi
,
Jeremy S. Abramson
,
Taha Al‐Juhaishi
,
Danielle M. Brander
,
Catherine C. Coombs
,
Richard R. Furman
,
Nitin Jain
,
Nadia Khan
,
Nakhle S. Saba
,
Jennifer Collins
,
Amer Beitinjaneh
,
Deborah M. Stephens
,
Jennifer A. Woyach
,
Mehdi Hamadani
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jtct.2025.06.002
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jtct.2025.06.002
Chimeric antigen receptor T-cell therapy (CAR T-cell) is a new treatment option for relapsed and/or refractory (R/R) chronic lymphocytic leukemia (CLL). Novel therapies including Bruton's tyrosine kinase inhibitors (BTK), covalent or noncovalent, and an inhibitor of the B-cell leukemia/lymphoma 2 protein (BCL-2), venetoclax, have replaced chemoimmunotherapy (CIT) regimens in the front-line and the R/R setting, and have relegated allogeneic hematopoietic cell transplantation (allo-HCT) to later treatment stages. Updating the 2016 clinical practice recommendations on allo-HCT in CLL is necessary to help guide contemporary clinical practice. A panel of 18 physicians with diverse expertise across different CLL treatment modalities and one methodologist participated in this effort. Any recommendation receiving ≥ 70% votes was considered a consensus. CAR T-cell therapy is recommended for patients not responding or relapsing after at least 2 lines of therapy consisting of a covalent BTK inhibitor and a BCL-2 inhibitor. In addition, CAR T-cell therapy is recommended for patients who subsequently received a noncovalent BTK inhibitor in the third-line or later setting, regardless of response. CAR T-cell therapy is also recommended in CLL relapsing after an allo-HCT, assuming that patients are fit for the procedure. In those CLL patients who are candidates, allo-HCT is recommended if disease is R/R to CAR T-cell therapy provided that an objective response is demonstrated prior to the allograft. Allo-HCT is also recommended in patients with clonally-related Richter transformation (RT) after demonstrating an objective response to front-line CIT or other treatments. CAR T-cell therapy is recommended in R/R RT. We emphasize the importance of enrolling patients in clinical trials whenever available to continue to advance the field and improve prognosis of R/R CLL. We acknowledge that there are unique clinical scenarios not covered herein which may require a case-by-case approach.
Related Topics
Concepts
Transplantation
Hematopoietic cell
Medicine
Immunology
Hematopoietic stem cell transplantation
Chronic lymphocytic leukemia
Chimeric antigen receptor
Leukemia
Haematopoiesis
Oncology
Stem cell
T cell
Internal medicine
Biology
Immune system
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jtct.2025.06.002
- OA Status
- hybrid
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411201825
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4411201825Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jtct.2025.06.002Digital Object Identifier
- Title
-
Clinical Practice Recommendations on the Role Of Allogeneic Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T-Cell Therapy in Patients With Chronic Lymphocytic Leukemia on Behalf of the American Society for Transplantation and Cellular TherapyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-11Full publication date if available
- Authors
-
Mohamed A. Kharfan‐Dabaja, Ambuj Kumar, Javier Pinilla‐Ibarz, Jennifer R. Brown, Mazyar Shadman, Farrukh T. Awan, Saad S. Kenderian, Tanya Siddiqi, Jeremy S. Abramson, Taha Al‐Juhaishi, Danielle M. Brander, Catherine C. Coombs, Richard R. Furman, Nitin Jain, Nadia Khan, Nakhle S. Saba, Jennifer Collins, Amer Beitinjaneh, Deborah M. Stephens, Jennifer A. Woyach, Mehdi HamadaniList of authors in order
- Landing page
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https://doi.org/10.1016/j.jtct.2025.06.002Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.jtct.2025.06.002Direct OA link when available
- Concepts
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Transplantation, Hematopoietic cell, Medicine, Immunology, Hematopoietic stem cell transplantation, Chronic lymphocytic leukemia, Chimeric antigen receptor, Leukemia, Haematopoiesis, Oncology, Stem cell, T cell, Internal medicine, Biology, Immune system, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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50Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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