Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID‐19 Article Swipe
José Miguel Rivera‐Caravaca
,
Iván J. Núñez‐Gil
,
David Vivas
,
María C. Viana‐Llamas
,
Aitor Uribarri
,
Víctor Manuel Becerra‐Muñoz
,
Daniela Trabattoni
,
Inmaculada Fernández Rozas
,
Gisela Feltes
,
Javier López‐País
,
Ibrahim El‐Battrawy
,
Carlos Macaya
,
Antonio Fernández-Ortı́z
,
Vicente Estrada
,
Francisco Marı́n
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/eci.13436
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/eci.13436
Background The coronavirus disease 2019 (COVID‐19) shows high morbidity and mortality, particularly in patients with concomitant cardiovascular diseases. Some of these patients are under oral anticoagulation (OAC) at admission, but to date, there are no data on the clinical profile, prognosis and risk factors of such patients during hospitalization for COVID‐19. Design Subanalysis of the international ‘real‐world’ HOPE COVID‐19 registry. All patients with prior OAC at hospital admission for COVID‐19 were suitable for the study. All‐cause mortality was the primary endpoint. Results From 1002 patients included, 110 (60.9% male, median age of 81.5 [IQR 75‐87] years, median Short‐Form Charlson Comorbidity Index [CCI] of 1 [IQR 1‐3]) were on OAC at admission, mainly for atrial fibrillation and venous thromboembolism. After propensity score matching, 67.9% of these patients died during hospitalization, which translated into a significantly higher mortality risk compared to patients without prior OAC (HR 1.53, 95% CI 1.08‐2.16). After multivariate Cox regression analysis, respiratory insufficiency during hospitalization (HR 6.02, 95% CI 2.18‐16.62), systemic inflammatory response syndrome (SIRS) during hospitalization (HR 2.29, 95% CI 1.34‐3.91) and the Short‐Form CCI (HR 1.24, 95% CI 1.03‐1.49) were the main risk factors for mortality in patients on prior OAC. Conclusions Compared to patients without prior OAC, COVID‐19 patients on OAC therapy at hospital admission showed lower survival and higher mortality risk. In these patients on OAC therapy, the prevalence of several comorbidities is high. Respiratory insufficiency and SIRS during hospitalization, as well as higher comorbidity, pointed out those anticoagulated patients with increased mortality risk.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/eci.13436
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13436
- OA Status
- bronze
- Cited By
- 52
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3094039314
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3094039314Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/eci.13436Digital Object Identifier
- Title
-
Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID‐19Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-10-20Full publication date if available
- Authors
-
José Miguel Rivera‐Caravaca, Iván J. Núñez‐Gil, David Vivas, María C. Viana‐Llamas, Aitor Uribarri, Víctor Manuel Becerra‐Muñoz, Daniela Trabattoni, Inmaculada Fernández Rozas, Gisela Feltes, Javier López‐País, Ibrahim El‐Battrawy, Carlos Macaya, Antonio Fernández-Ortı́z, Vicente Estrada, Francisco Marı́nList of authors in order
- Landing page
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https://doi.org/10.1111/eci.13436Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13436Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.13436Direct OA link when available
- Concepts
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Medicine, Internal medicine, Atrial fibrillation, Comorbidity, Concomitant, Proportional hazards model, Coronavirus disease 2019 (COVID-19), Propensity score matching, Clinical endpoint, Charlson comorbidity index, Disease, Clinical trial, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
-
52Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 5, 2023: 8, 2022: 20, 2021: 16, 2020: 3Per-year citation counts (last 5 years)
- References (count)
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46Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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