Clinical Utility of BRAF, NRAS, and TERT Promoter Mutation in Preoperative Thyroid Fine-Needle Aspiration Biopsy: A Diagnostic Study From Dharmais Cancer Hospital Article Swipe
Adhitya Bayu Perdana
,
Rizky Ifandriani Putri
,
Rachmawati Rachmawati
,
Bob Andinata
,
Bayu Brahma
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.31557/apjcp.2020.21.11.3267
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.31557/apjcp.2020.21.11.3267
Molecular testing of thyroid nodules becomes important for improving the accuracy of fine-needle aspiration biopsy (FNAB). This study aimed to investigate the diagnostic utility of BRAF, NRAS, and TERT promoter mutation in thyroid nodules at Dharmais Cancer Hospital.Methods: We performed a prospective diagnostic study involving 50 patients with thyroid nodules who needed surgery between September 2013 and August 2014. Mutational hotspots in BRAF exon 15, NRAS exon 3, and TERT promoter region were analyzed by Sanger sequencing from FNAB specimens. Cytology and molecular data were compared to histopathology results.Result: Of the 50 cases included in the analysis, 39 cases (78%) were thyroid malignancies. Mutations of BRAF, NRAS, and TERT promoter were detected in 31% (12/39), 18% (7/39), and 13% (5/39) cases, respectively. BRAF and NRAS mutations were found mutually exclusive, while all of TERT promoter mutation was found coexistent either with BRAF (40%) or NRAS (60%). The combination of FNAB cytology and molecular testing resulted in 69% sensitivity, 100% specificity, 100% positive predictive value, 48% negative predictive value, and 76% accuracy.Conclusion: Molecular testing of BRAF, NRAS, and TERT mutations improve the sensitivity of thyroid FNAB and is beneficial for more definitive treatment in selective cases. However, the NPV is relatively low to avoid the need for diagnostic surgery. Therefore, further studies to identify more sensitive methods and more comprehensive molecular markers in the diagnosis of thyroid nodules are needed.
Related Topics
Concepts
Neuroblastoma RAS viral oncogene homolog
Thyroid nodules
Medicine
Sanger sequencing
Thyroid cancer
Thyroid
Biopsy
Pathology
Fine-needle aspiration
Cancer
Internal medicine
Oncology
KRAS
Mutation
Gene
Biology
Genetics
Colorectal cancer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.31557/apjcp.2020.21.11.3267
- http://journal.waocp.org/article_89347_bed0bdb41c89b2f807aed1a812a968f1.pdf
- OA Status
- gold
- Cited By
- 12
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3108268637
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3108268637Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.31557/apjcp.2020.21.11.3267Digital Object Identifier
- Title
-
Clinical Utility of BRAF, NRAS, and TERT Promoter Mutation in Preoperative Thyroid Fine-Needle Aspiration Biopsy: A Diagnostic Study From Dharmais Cancer HospitalWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-11-01Full publication date if available
- Authors
-
Adhitya Bayu Perdana, Rizky Ifandriani Putri, Rachmawati Rachmawati, Bob Andinata, Bayu BrahmaList of authors in order
- Landing page
-
https://doi.org/10.31557/apjcp.2020.21.11.3267Publisher landing page
- PDF URL
-
https://journal.waocp.org/article_89347_bed0bdb41c89b2f807aed1a812a968f1.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://journal.waocp.org/article_89347_bed0bdb41c89b2f807aed1a812a968f1.pdfDirect OA link when available
- Concepts
-
Neuroblastoma RAS viral oncogene homolog, Thyroid nodules, Medicine, Sanger sequencing, Thyroid cancer, Thyroid, Biopsy, Pathology, Fine-needle aspiration, Cancer, Internal medicine, Oncology, KRAS, Mutation, Gene, Biology, Genetics, Colorectal cancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 1, 2023: 4, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
53Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.76257173 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |