Clinically representative rodent model for biomedical device-associated infection Article Swipe
Hyeongjoon Lee
,
Soo-Kyung Choi
,
Suenghwan Jo
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.30579/mbse.2023.6.1.26
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.30579/mbse.2023.6.1.26
Bacterial biofilms in the body commonly occur following the implantation of a biomedical device.A mature biofilm results in an extracellular matrix covering the aggregated bacteria and provides protection against antibiotics or the native immune system, rendering diagnosis and treatment difficult.Experiments to eradicate or prevent biofilm formation have been widely performed, with many showing potential for application in vivo.To test the safety and in vivo efficacy of these novel methods, a reliable preclinical animal model is necessary.Here we developed a simple animal model that can be used to recreate medical device-associated infections in vivo.Reproducible Staphylococcus aureus bacterial biofilms were formed on a titanium implant and confirmed by the counting of colony-forming units after sonication and in vivo bioluminescence measurements.We tested our strategy for developing both acute and late-onset infections and confirmed that the model successfully demonstrated bacterial biofilm formation on titanium surfaces, representing acute infection.We believe that this model will be a good option for validating the efficacy and safety of antibacterial strategies for orthopedic surgery.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.30579/mbse.2023.6.1.26
- http://www.embse.org/journal/download_pdf.php?doi=10.30579/mbse.2023.6.1.26
- OA Status
- diamond
- References
- 23
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4318472482
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4318472482Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.30579/mbse.2023.6.1.26Digital Object Identifier
- Title
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Clinically representative rodent model for biomedical device-associated infectionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-30Full publication date if available
- Authors
-
Hyeongjoon Lee, Soo-Kyung Choi, Suenghwan JoList of authors in order
- Landing page
-
https://doi.org/10.30579/mbse.2023.6.1.26Publisher landing page
- PDF URL
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https://www.embse.org/journal/download_pdf.php?doi=10.30579/mbse.2023.6.1.26Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.embse.org/journal/download_pdf.php?doi=10.30579/mbse.2023.6.1.26Direct OA link when available
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Rodent model, Rodent, Computational biology, Medicine, Biology, Ecology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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23Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| institutions_distinct_count | 3 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.5600000023841858 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.00689452 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |