Clinically significant incidental QTc prolongation is subject to within‐individual variability Article Swipe
Itai Gueta
,
Robert Klempfner
,
Noa Markovits
,
Hillel Halkin
,
Shlomo Segev
,
David Rott
,
Yael Peled
,
Ronen Loebstein
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1111/anec.12699
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1111/anec.12699
Background Prolonged QTc interval observed in daily practice is often deemed to be drug induced and might result in drug discontinuation, with possible therapeutic consequences. However, whether clinically significant prolonged QTc may be due to within‐individual variability occurs has yet to be described. Methods A retrospective cohort study documenting within‐individual QTc variability in subjects attending annual routine medical evaluation. At each visit, QT interval was measured and corrected for heart rate using Bazett and three other commonly used formulae. Outcome measures were rates of ΔQTc ≥60 msec, absolute QTc ≥500 msec and QTc ≥25% from baseline. Results A total of 188 subjects [54 (29%)] females were recruited. Mean age at first ECG was 54 ± 12.8 years with mean time interval of 12.2 ± 1.1 months between measurements. Mean Bazett QTc was higher compared to the other 3 formulae: 412 ± 20 vs. 400 ± 16 msec. Using Bazett formula, 18/188 (9.6%) and 5/188 (2.7%) subjects showed at least one measurement with ΔQTc ≥60 msec and QTc ≥500 msec, respectively. Of the former, 5/18 (27.8%) showed QTc ≥25% prolongation. In multivariate analysis, QTc ≥500 msec was significantly associated with number of measurements (HR: 5.01, 95%CI: 1.21–20.78, p = .026) with no effect of other known confounders. Lower rates were demonstrated with the other three formulae. Conclusion In clinical practice, significant prolonged QTc may be attributed to within‐individual variability, particularly when adjusting the QT interval with Bazett correction. This should be taken into consideration when decisions on changing current drug regimens are to be made.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/anec.12699
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/anec.12699?download=true
- OA Status
- bronze
- Cited By
- 14
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2972833955
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2972833955Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/anec.12699Digital Object Identifier
- Title
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Clinically significant incidental QTc prolongation is subject to within‐individual variabilityWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
-
2019-09-09Full publication date if available
- Authors
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Itai Gueta, Robert Klempfner, Noa Markovits, Hillel Halkin, Shlomo Segev, David Rott, Yael Peled, Ronen LoebsteinList of authors in order
- Landing page
-
https://doi.org/10.1111/anec.12699Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/anec.12699?download=trueDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/anec.12699?download=trueDirect OA link when available
- Concepts
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QT interval, Medicine, Discontinuation, Prolongation, Heart rate, Internal medicine, Confounding, Electrocardiography, Cardiology, Cohort, Anesthesia, Blood pressureTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 3, 2022: 3, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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19Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I16391192, https://openalex.org/I2799810450 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.82272997 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |