Clonal Dynamics in the Male Germline from Development to Next Generation Article Swipe
Tatsuro Ikeda
,
Maurice Langhinrichs
,
Tamar Nizharadze
,
Chieko Koike
,
Yuzuru Kato
,
Katsushi Yamaguchi
,
Shuji Shigenobu
,
Kana Yoshido
,
Shinnosuke Suzuki
,
Toshinori Nakagawa
,
Ayumi Maruyama
,
Seiya Mizuno
,
Satoru Takahashi
,
Hans‐Reimer Rodewald
,
Thomas Höfer
,
Shosei Yoshida
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.09.02.672339
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.09.02.672339
Germ cells support the continuation and evolution of species. In mammals, the germline trajectory originates from a limited number of primordial germ cells (PGCs), persists through the lifespan of the organism, and continues across generations. Yet, the dynamics and contributions of individual PGC lineages remain enigmatic. Here, we employ Polylox 1 DNA barcoding to unveil the clonal dynamics of mouse male germline from development to the next generation and find that disparate probabilities for trans-generational inheritance from individual PGCs are established in early embryogenesis and persist throughout adulthood. Indeed, >30% of PCG clones are lost before colonisation in the testis, suggesting early quality control, with surviving PGC clones expanding unevenly. Thereafter, clone sizes remain stable lifelong, and inheritance to offspring is proportional to clone size, arguing against strong variability in sperm fitness. Mathematical analysis of the barcoding data indicates that early clonal dynamics follow probabilistic rules, whereas the subsequent compartmentalisation of clones into seminiferous tubules in the testis preserves the clonal repertoire and may guard against large-scale selection of mutant clones. This study defines the quantitative dynamics of male germline development and transmission and thus reveals constraints for how de novo mutations that arise in germ cells can be transmitted to offspring.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.09.02.672339
- https://www.biorxiv.org/content/biorxiv/early/2025/09/02/2025.09.02.672339.full.pdf
- OA Status
- green
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413924879
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4413924879Canonical identifier for this work in OpenAlex
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https://doi.org/10.1101/2025.09.02.672339Digital Object Identifier
- Title
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Clonal Dynamics in the Male Germline from Development to Next GenerationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-09-02Full publication date if available
- Authors
-
Tatsuro Ikeda, Maurice Langhinrichs, Tamar Nizharadze, Chieko Koike, Yuzuru Kato, Katsushi Yamaguchi, Shuji Shigenobu, Kana Yoshido, Shinnosuke Suzuki, Toshinori Nakagawa, Ayumi Maruyama, Seiya Mizuno, Satoru Takahashi, Hans‐Reimer Rodewald, Thomas Höfer, Shosei YoshidaList of authors in order
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https://doi.org/10.1101/2025.09.02.672339Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2025/09/02/2025.09.02.672339.full.pdfDirect link to full text PDF
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-
YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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-
https://www.biorxiv.org/content/biorxiv/early/2025/09/02/2025.09.02.672339.full.pdfDirect OA link when available
- Concepts
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Germline, Dynamics (music), Biology, Genetics, Sociology, Pedagogy, GeneTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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57Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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