Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20 Article Swipe

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Subclade Cluster (spacecraft) Enterovirus Medicine Pediatrics Epidemiology Demography Phylogenetic tree Internal medicine Virology Biology Virus Clade Sociology Biochemistry Programming language Gene Computer science

Sofie Midgley , Kimberley Benschop , Robert Dyrdak , Audrey Mirand , Jean‐Luc Bailly , Sibylle Bierbaum , Stephan Buderus , Sindy Böttcher , Anna‐Maria Eis‐Hübinger , Mario Hönemann , Veronika Vorobieva Solholm Jensen , Ulla Birgitte Hartling , Cécile Henquell , Marcus Panning , Marianne Kragh Thomsen , Emma B. Hodcroft , Adam Meijer ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.2807/1560-7917.es.2020.25.2.1900749 · OA: W3000322773

Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 January 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 patients required hospitalisation and five had severe neurologic manifestations. Phylogenetic analysis revealed two clusters in the B3 subclade and subclade A2/D. This circulation of EV-D68 associated with neurological manifestations stresses the importance of surveillance and diagnostics beyond expected peak years.