Cocoa Flavonoids Reduce Inflammation and Oxidative Stress in a Myocardial Ischemia-Reperfusion Experimental Model Article Swipe
Sajeela Ahmed
,
Naseer Ahmed
,
Alessio Rungatscher
,
Daniele Linardi
,
Bibi Kulsoom
,
Giulio Innamorati
,
Sultan Ayoub Meo
,
Mebratu Alebachew Gebrie
,
Romel Mani
,
Flavia Merigo
,
Flavia Guzzo
,
Giuseppe Faggian
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/antiox9020167
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/antiox9020167
Consumption of flavonoid-rich nutraceuticals has been associated with a reduction in coronary events. The present study analyzed the effects of cocoa flavonols on myocardial injury following acute coronary ischemia-reperfusion (I/R). A commercially available cocoa extract was identified by chromatographic mass spectrometry. Nineteen different phenolic compounds were identified and 250 mg of flavan-3-ols (procyanidin) were isolated in 1 g of extract. Oral administration of cocoa extract in incremental doses from 5 mg/kg up to 25 mg/kg daily for 15 days in Sprague Dawley rats (n = 30) produced a corresponding increase of blood serum polyphenols and become constant after 15 mg/kg. Consequently, the selected dose (15 mg/kg) of cocoa extract was administered orally daily for 15 days in a treated group (n = 10) and an untreated group served as control (n = 10). Both groups underwent surgical occlusion of the left anterior descending coronary artery and reperfusion. Cocoa extract treatment significantly reversed membrane peroxidation, nitro-oxidative stress, and decreased inflammatory markers (IL-6 and NF-kB) caused by myocardial I/R injury and enhanced activation of both p-Akt and p-Erk1/2. Daily administration of cocoa extract in rats is protective against myocardial I/R injury and attenuate nitro-oxidative stress, inflammation, and mitigates myocardial apoptosis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antiox9020167
- https://www.mdpi.com/2076-3921/9/2/167/pdf?version=1582776947
- OA Status
- gold
- Cited By
- 34
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3006919862
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3006919862Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/antiox9020167Digital Object Identifier
- Title
-
Cocoa Flavonoids Reduce Inflammation and Oxidative Stress in a Myocardial Ischemia-Reperfusion Experimental ModelWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-02-18Full publication date if available
- Authors
-
Sajeela Ahmed, Naseer Ahmed, Alessio Rungatscher, Daniele Linardi, Bibi Kulsoom, Giulio Innamorati, Sultan Ayoub Meo, Mebratu Alebachew Gebrie, Romel Mani, Flavia Merigo, Flavia Guzzo, Giuseppe FaggianList of authors in order
- Landing page
-
https://doi.org/10.3390/antiox9020167Publisher landing page
- PDF URL
-
https://www.mdpi.com/2076-3921/9/2/167/pdf?version=1582776947Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2076-3921/9/2/167/pdf?version=1582776947Direct OA link when available
- Concepts
-
Oxidative stress, Flavonols, Pharmacology, Myocardial infarction, Reperfusion injury, Medicine, Flavonoid, Inflammation, Proanthocyanidin, Ischemia, Antioxidant, Chemistry, Internal medicine, Polyphenol, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
34Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 6, 2023: 5, 2022: 6, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
44Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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