CODEL: phase III study of RT, RT + TMZ, or TMZ for newly diagnosed 1p/19q codeleted oligodendroglioma. Analysis from the initial study design Article Swipe
Kurt A. Jaeckle
,
Karla V. Ballman
,
Martin J. van den Bent
,
Caterina Giannini
,
Evanthia Galanis
,
Paul D. Brown
,
Robert B. Jenkins
,
J. Gregory Cairncross
,
Wolfgang Wick
,
Michael Weller
,
Kenneth Aldape
,
Jesse G. Dixon
,
S. Keith Anderson
,
Jane H. Cerhan
,
Jeffrey S. Wefel
,
Martin Klein
,
Stuart A. Grossman
,
David Schiff
,
Jeffrey J. Raizer
,
F. Dhermain
,
Donald G. Nordstrom
,
Patrick J. Flynn
,
Michael A. Vogelbaum
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noaa168
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noaa168
Background We report the analysis involving patients treated on the initial CODEL design. Methods Adults (>18) with newly diagnosed 1p/19q World Health Organization (WHO) grade III oligodendroglioma were randomized to radiotherapy (RT; 5940 centigray ) alone (arm A); RT with concomitant and adjuvant temozolomide (TMZ) (arm B); or TMZ alone (arm C). Primary endpoint was overall survival (OS), arm A versus B. Secondary comparisons were performed for OS and progression-free survival (PFS), comparing pooled RT arms versus TMZ-alone arm. Results Thirty-six patients were randomized equally. At median follow-up of 7.5 years, 83.3% (10/12) TMZ-alone patients progressed, versus 37.5% (9/24) on the RT arms. PFS was significantly shorter in TMZ-alone patients compared with RT patients (hazard ratio [HR] = 3.12; 95% CI: 1.26, 7.69; P = 0.014). Death from disease progression occurred in 3/12 (25%) of TMZ-alone patients and 4/24 (16.7%) on the RT arms. OS did not statistically differ between arms (comparison underpowered). After adjustment for isocitrate dehydrogenase (IDH) status (mutated/wildtype) in a Cox regression model utilizing IDH and RT treatment status as covariables (arm C vs pooled arms A + B), PFS remained shorter for patients not receiving RT (HR = 3.33; 95% CI: 1.31, 8.45; P = 0.011), but not OS ((HR = 2.78; 95% CI: 0.58, 13.22, P = 0.20). Grade 3+ adverse events occurred in 25%, 42%, and 33% of patients (arms A, B, and C). There were no differences between arms in neurocognitive decline comparing baseline to 3 months. Conclusions TMZ-alone patients experienced significantly shorter PFS than patients treated on the RT arms. The ongoing CODEL trial has been redesigned to compare RT + PCV versus RT + TMZ.
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- Language
- en
- Landing Page
- https://doi.org/10.1093/neuonc/noaa168
- https://academic.oup.com/neuro-oncology/article-pdf/23/3/457/36722797/noaa168.pdf
- OA Status
- hybrid
- Cited By
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- References
- 27
- Related Works
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- OpenAlex ID
- https://openalex.org/W3043701315
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3043701315Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/neuonc/noaa168Digital Object Identifier
- Title
-
CODEL: phase III study of RT, RT + TMZ, or TMZ for newly diagnosed 1p/19q codeleted oligodendroglioma. Analysis from the initial study designWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-07-13Full publication date if available
- Authors
-
Kurt A. Jaeckle, Karla V. Ballman, Martin J. van den Bent, Caterina Giannini, Evanthia Galanis, Paul D. Brown, Robert B. Jenkins, J. Gregory Cairncross, Wolfgang Wick, Michael Weller, Kenneth Aldape, Jesse G. Dixon, S. Keith Anderson, Jane H. Cerhan, Jeffrey S. Wefel, Martin Klein, Stuart A. Grossman, David Schiff, Jeffrey J. Raizer, F. Dhermain, Donald G. Nordstrom, Patrick J. Flynn, Michael A. VogelbaumList of authors in order
- Landing page
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https://doi.org/10.1093/neuonc/noaa168Publisher landing page
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https://academic.oup.com/neuro-oncology/article-pdf/23/3/457/36722797/noaa168.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://academic.oup.com/neuro-oncology/article-pdf/23/3/457/36722797/noaa168.pdfDirect OA link when available
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Oligodendroglioma, Medicine, Oncology, Phases of clinical research, Internal medicine, Nuclear medicine, Glioma, Cancer research, Chemotherapy, AstrocytomaTop concepts (fields/topics) attached by OpenAlex
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105Total citation count in OpenAlex
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2025: 17, 2024: 26, 2023: 18, 2022: 25, 2021: 17Per-year citation counts (last 5 years)
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27Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.progression | 130 |
| abstract_inverted_index.(>18) | 16 |
| abstract_inverted_index.Organization | 23 |
| abstract_inverted_index.radiotherapy | 31 |
| abstract_inverted_index.temozolomide | 44 |
| abstract_inverted_index.dehydrogenase | 158 |
| abstract_inverted_index.significantly | 106, 249 |
| abstract_inverted_index.statistically | 148 |
| abstract_inverted_index.neurocognitive | 238 |
| abstract_inverted_index.underpowered). | 153 |
| abstract_inverted_index.progression-free | 70 |
| abstract_inverted_index.oligodendroglioma | 27 |
| abstract_inverted_index.(mutated/wildtype) | 161 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5023657472 |
| countries_distinct_count | 6 |
| institutions_distinct_count | 23 |
| corresponding_institution_ids | https://openalex.org/I2801572250, https://openalex.org/I4210146710 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.98169539 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |