Biological and Pharmaceutical Bulletin • Vol 42 • No 8
Coefficient of Determination between Estimated and Measured Renal Function in Japanese Patients with Sarcopenia May Be Improved by Adjusting for Muscle Mass and Sex: A Prospective Study
June 2019 • Sakura Nakatani, Keisuke Maeda, Junji Akagi, Misato Ichigi, Marina Murakami, Yoshihiko Harada, Sara Utsumi, Masaki Fukunaga, Yuki Narita, Yuki Kondo,…
Creatinine (Cr) levels are strongly affected by muscle mass, and the estimated glomerular filtration rate (eGFR), a measure based on serum creatinine (SCr), is often overestimated in patients with sarcopenia. To evaluate the coefficient of determination (R<sup>2</sup>) between eGFR and the actual measured value, we performed a linear regression analysis of a modified GFR (mGFR: measured Cr clearance × 0.715) and various renal function estimates adjusted for muscle mass in 19 patients with sarcopenia. The eGFR valu…