Cognition in Patients With Memory Difficulties and Dementia Relative to APOE e4 Status Article Swipe
Knut Hestad
,
Knut Engedal
,
Peter Otto Horndalsveen
,
Bjørn Heine Strand
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fpsyg.2021.686036
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fpsyg.2021.686036
The aim of this study was to investigate whether cognitive performance was equally influenced by Apolipoprotein E (APOE, with its three alleles, e2, e3, and e4) in patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s disease (AD). In addition, we examined a group of patients with a combination of Vascular dementia (VaD) and AD (VaD/AD). We asked if the APOE e4 allele influenced cognition in these patient groups in the same way. Our study comprised data from 1,991 patients (55% women), with a mean age of 70.9 years (SD 10.8) and 12.1 years of education (SD 3.8). Of them, 1,111 (56%) had at least one APOE e4 allele; 871 (44%) had one and 240 (12%) had two e4 alleles. Three neurocognitive tests were used to measure cognition: the Mini Mental State Examination (MMSE), the 10-word test of the Consortium to Establish a Registry for Alzheimer’s Disease Word List (CERAD-WL) (immediate and delayed recall), and the Trail Making Test Part A (TMTA). The APOE genotypes were regressed against cognitive function using linear regression, adjusting for diagnosis, age, sex, and education. The interaction diagnosis ∗ APOE was investigated. The allele type had the largest effect on cognitive performance assessed by the CERAD-WL delayed recall test, less for the other tests. Those without the e4 type scored 0.7 units better than those with e4 allele(s) ( p < 0.001). Furthermore, there was a significant inverse dose-response pattern between number of e4 alleles and cognitive performance; those with one allele scored 0.4 units better than those with two alleles ( p = 0.006), and those without e4 scored 0.7 units better than those with one e4 ( p < 0.001). This pattern did not differ between the four diagnostic groups studied.
Related Topics
Concepts
Apolipoprotein E
Cognition
Dementia
Neurocognitive
Psychology
Recall
Boston Naming Test
Alzheimer's disease
Allele
Audiology
Mini–Mental State Examination
Cognitive test
Effects of sleep deprivation on cognitive performance
Medicine
Clinical psychology
Disease
Internal medicine
Psychiatry
Neuropsychology
Cognitive impairment
Genetics
Cognitive psychology
Biology
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fpsyg.2021.686036
- https://www.frontiersin.org/articles/10.3389/fpsyg.2021.686036/pdf
- OA Status
- gold
- Cited By
- 2
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3166686081
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3166686081Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fpsyg.2021.686036Digital Object Identifier
- Title
-
Cognition in Patients With Memory Difficulties and Dementia Relative to APOE e4 StatusWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-14Full publication date if available
- Authors
-
Knut Hestad, Knut Engedal, Peter Otto Horndalsveen, Bjørn Heine StrandList of authors in order
- Landing page
-
https://doi.org/10.3389/fpsyg.2021.686036Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fpsyg.2021.686036/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fpsyg.2021.686036/pdfDirect OA link when available
- Concepts
-
Apolipoprotein E, Cognition, Dementia, Neurocognitive, Psychology, Recall, Boston Naming Test, Alzheimer's disease, Allele, Audiology, Mini–Mental State Examination, Cognitive test, Effects of sleep deprivation on cognitive performance, Medicine, Clinical psychology, Disease, Internal medicine, Psychiatry, Neuropsychology, Cognitive impairment, Genetics, Cognitive psychology, Biology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2023: 1, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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