Cognitive flexibility in post-traumatic stress disorder: Sustained interference associated with altered modulation of cortical oscillatory activity during task-switching Article Swipe
Mihai Popescu
,
Elena-Anda Popescu
,
Thomas J. DeGraba
,
John Hughes
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.nicl.2022.103297
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.nicl.2022.103297
Post-traumatic stress disorder (PTSD) is associated with deficits in cognitive flexibility, with evidence suggesting that these deficits may be a risk factor for the development of core PTSD symptoms. Understanding the neurophysiological substrate of this association could aid the development of effective therapies for PTSD. In this study, we investigated the relationship between post-traumatic stress severity (PTSS) in service members with combat exposure and the modulation of cortical oscillatory activity during a test of cognitive flexibility. Participants were assigned to three groups based on PTSS scores: low (well below a threshold consistent with a diagnosis of PTSD, n = 30), moderate (n = 32), and high (n = 29) symptom severity. Magnetoencephalography data were recorded while participants performed a cued rule-switching task in which two matching rules were repeated or switched across consecutive trials. Participants with high PTSS had longer reaction times for both switch and repeat trials, and showed evidence of sustained residual interference during repeat trials. During the cue-stimulus interval, participants with moderate and high PTSS showed higher relative theta power in switch trials over left dorsolateral prefrontal cortex (DLPFC). After test-stimulus onset, participants with high PTSS showed less suppression of beta band activity, which was present over multiple prefrontal, parietal, and temporal regions in switch trials, but it was confined to ventromedial prefrontal cortex in repeat trials. Higher theta band activity is a marker of effortful voluntary shifting of attention, while lower suppression of beta band activity reflects difficulties with inhibition of competing perceptual information and courses of action. These findings are consistent with a role for altered suppression of beta band activity, which can be due to less effective top-down bias signals exerted by DLPFC, in the etiology of cognitive flexibility deficits in PTSD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.nicl.2022.103297
- OA Status
- gold
- Cited By
- 11
- References
- 94
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4311900377
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4311900377Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.nicl.2022.103297Digital Object Identifier
- Title
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Cognitive flexibility in post-traumatic stress disorder: Sustained interference associated with altered modulation of cortical oscillatory activity during task-switchingWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-12-19Full publication date if available
- Authors
-
Mihai Popescu, Elena-Anda Popescu, Thomas J. DeGraba, John HughesList of authors in order
- Landing page
-
https://doi.org/10.1016/j.nicl.2022.103297Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.nicl.2022.103297Direct OA link when available
- Concepts
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Cognitive flexibility, Psychology, Ventromedial prefrontal cortex, Prefrontal cortex, Magnetoencephalography, Cognition, Stimulus (psychology), Cued speech, Audiology, Neuroscience, Electroencephalography, Medicine, Cognitive psychologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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11Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 3, 2023: 3Per-year citation counts (last 5 years)
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94Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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