Cognitive impairment in patients with Neuro‐Sjögren Article Swipe
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· 2020
· Open Access
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· DOI: https://doi.org/10.1002/acn3.51123
Objective Extraglandular neurological manifestations of Sjögren’s syndrome are increasingly recognized, defining the disease entity of Neuro‐Sjögren. Neuropsychological assessment of patients with Sjögren’s syndrome has hitherto been performed on predominantly rheumatological cohorts. These studies revealed a wide variety of prevalence rates for cognitive impairment (22–80%), while variable cut‐off criteria for detection of cognitive impairment were applied. Attentional functions have not yet been thoroughly investigated in these patients, although they clearly represent relevant aspects of cognitive functioning in daily life. Methods We therefore conducted extensive neuropsychological assessment based on two neuropsychological test batteries [i.e., the extended German version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD‐PLUS), and the test battery for attentional performance (TAP) as a well‐established assessment of attentional functions in the German‐speaking part of Europe]. Results Sixty‐four patients with Neuro‐Sjögren, who were treated at our university hospital between December 2016 and January 2019, were included. Evidence for the presence of cognitive impairment was found in 55% of patients with Neuro‐Sjögren. The degree of cognitive impairment ranged from mild (38%) to severe (17%). Attentional and mnemonic subtests showed pronounced cognitive impairment in patients with Neuro‐Sjögren. Interpretation Our results suggest that a substantial proportion of patients with Neuro‐Sjögren suffer from cognitive impairment, putatively as a corollary of attentional deficits, which might exert adverse effects on occupational abilities, other cognitive functions, and social role functioning.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/acn3.51123
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51123
- OA Status
- gold
- Cited By
- 20
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3038206929
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3038206929Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/acn3.51123Digital Object Identifier
- Title
-
Cognitive impairment in patients with Neuro‐SjögrenWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-07-06Full publication date if available
- Authors
-
Tabea Seeliger, Lena Jacobsen, Merle K. Hendel, Lena Bönig, Nils Prenzler, Thea Thiele, Diana Ernst, Torsten Witte, Martin Stangel, Bruno Kopp, Thomas SkripuletzList of authors in order
- Landing page
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https://doi.org/10.1002/acn3.51123Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51123Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51123Direct OA link when available
- Concepts
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Medicine, Neuropsychology, Cognition, Neuropsychological assessment, Audiology, Disease, Neuropsychological test, Pediatrics, Clinical psychology, Psychiatry, PathologyTop concepts (fields/topics) attached by OpenAlex
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20Total citation count in OpenAlex
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2025: 3, 2024: 5, 2023: 2, 2022: 8, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5001155888 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I34809795 |
| citation_normalized_percentile.value | 0.82238488 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |