COL11A1 is overexpressed in recurrent non-small cell lung cancer and promotes cell proliferation, migration, invasion and drug resistance Article Swipe
Lihua Shen
,
Min Yang
,
Qionghua Lin
,
Zhongwei Zhang
,
Biao Zhu
,
Changhong Miao
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3892/or.2016.4869
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3892/or.2016.4869
Collagen type XI α1 (COL11A1), a minor fibrillar collagen, has been demonstrated to be involved in cell proliferation, migration and the tumorigenesis of many human malignancies. Previous studies have shown that COL11A1 may be a valuable diagnostic marker for non-small cell lung carcinoma (NSCLC). However, its biological function in NSCLC progression remains largely unclear. In the present study, we investigated the expression levels of COL11A1 in different human NSCLC samples, and found that COL11A1 was overexpressed in NSCLC with lymph node metastasis and in recurrent NSCLC tissues. We also revealed that COL11A1 promoted the cell proliferation, migration and invasion of NSCLC cell lines in vitro. Furthermore, our results highlighted the importance of COL11A1 in chemoresistance to cisplatin. Mechanistically, we found that the effects of the overexpression of COL11A1 in NSCLC cells were mediated by Smad signaling. Collectively, our findings suggest that COL11A1 may sever as a biomarker for metastatic NSCLC, and can be used to predict recurrence after surgical resection. Therapeutic approaches targeting COL11A1 may facilitate the optimization of cisplatin treatment of NSCLC by overcoming chemoresistance.
Related Topics
Concepts
Cisplatin
Cancer research
Cell growth
Carcinogenesis
Lung cancer
Molecular medicine
Oncogene
Cell cycle
Cell
Biomarker
Metastasis
Biology
Cancer
Medicine
Oncology
Internal medicine
Chemotherapy
Genetics
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/or.2016.4869
- http://www.spandidos-publications.com/10.3892/or.2016.4869/download
- OA Status
- bronze
- Cited By
- 105
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2412882418
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2412882418Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/or.2016.4869Digital Object Identifier
- Title
-
COL11A1 is overexpressed in recurrent non-small cell lung cancer and promotes cell proliferation, migration, invasion and drug resistanceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
-
2016-06-10Full publication date if available
- Authors
-
Lihua Shen, Min Yang, Qionghua Lin, Zhongwei Zhang, Biao Zhu, Changhong MiaoList of authors in order
- Landing page
-
https://doi.org/10.3892/or.2016.4869Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/or.2016.4869/downloadDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
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https://www.spandidos-publications.com/10.3892/or.2016.4869/downloadDirect OA link when available
- Concepts
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Cisplatin, Cancer research, Cell growth, Carcinogenesis, Lung cancer, Molecular medicine, Oncogene, Cell cycle, Cell, Biomarker, Metastasis, Biology, Cancer, Medicine, Oncology, Internal medicine, Chemotherapy, Genetics, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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105Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 10, 2023: 6, 2022: 17, 2021: 24Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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