Colchicine versus Physical Therapy in Knee Osteoarthritis Article Swipe
George Ovidiu Cioroianu
,
Alesandra Florescu
,
Anca Emanuela Mușetescu
,
Teodor Nicuşor Sas
,
Otilia Constantina Rogoveanu
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/life12091297
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/life12091297
Background: The treatment of osteoarthritis remains a major challenge due to the unavailability of a disease-modifying medication and the limitations of current therapeutic perspectives, which mainly target the symptoms, not the disease itself. The purpose of our study is to compare the efficacy of colchicine treatment versus physical therapy. Methods: The study included 62 patients diagnosed with knee osteoarthritis (KOA) according to the American College of Rheumatology (ACR) criteria, hospitalized within the time frame of October 2020–March 2022 in the Department of Rehabilitation Medicine and Physical Therapy of the Emergency Clinical County Hospital of Craiova. The participants were randomly divided into two groups. The observation period was 16 weeks long. The first group (31 patients) received colchicine at a dosage of 1 mg/day together with analgesics (acetaminophen < 2 g/day), while the second group (31 patients) received analgesics (acetaminophen < 2 g/day) together with a 16-week plan of physiotherapy. Results: Group II, in which patients underwent physical therapy, demonstrated a statistically significant decrease in both left (p < 0.001) and right (p = 0.012) knee VAS and WOMAC (p = 0.038) scores at 16 weeks, compared to the group treated with colchicine. Regarding the MSUS examination at 16 weeks, there were no significant changes in the structural abnormalities and no improvement in cartilage aspect or thickness. Higher BMI was associated with higher WOMAC score (p = 0.012), but not with higher VAS score (p = 0.062). Cholesterol and triglyceride levels were associated with high WOMAC (p < 0.001; p = 0.021) and high VAS (p = 0.023; p < 0.001) scores. Conclusions: Our study monitored VAS and WOMAC scores in two groups of patients with KOA, showing that physical therapy is more effective than colchicine in reducing symptoms. We found no statistically significant difference in musculoskeletal ultrasound (MSUS) feature improvement during the 16-week study.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/life12091297
- https://www.mdpi.com/2075-1729/12/9/1297/pdf?version=1661338030
- OA Status
- gold
- Cited By
- 7
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4293218908
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4293218908Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/life12091297Digital Object Identifier
- Title
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Colchicine versus Physical Therapy in Knee OsteoarthritisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-08-24Full publication date if available
- Authors
-
George Ovidiu Cioroianu, Alesandra Florescu, Anca Emanuela Mușetescu, Teodor Nicuşor Sas, Otilia Constantina RogoveanuList of authors in order
- Landing page
-
https://doi.org/10.3390/life12091297Publisher landing page
- PDF URL
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https://www.mdpi.com/2075-1729/12/9/1297/pdf?version=1661338030Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2075-1729/12/9/1297/pdf?version=1661338030Direct OA link when available
- Concepts
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Medicine, Osteoarthritis, WOMAC, Internal medicine, Physical therapy, Rheumatology, Colchicine, Alternative medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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