Coleus aromaticus Benth.—A Plant with Strong Anticancer and Antioxidant Potential In Vitro Article Swipe
Justyna Stefanowicz-Hajduk
,
Anna Hering
,
Rafał Hałasa
,
Szymon Masiak
,
Karolina Turczyn
,
J. Renata Ochocka
,
Monika Asztemborska
,
Szymon Masiak
,
Karolina Turczyn
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ph18111756
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ph18111756
Background/Objectives: Gastrointestinal cancers, including gastric and colon cancers, constitute a serious threat to global health due to their high incidence and limited treatment outcomes. Thus, natural products are becoming increasingly popular as potential chemopreventive agents. Coleus aromaticus Benth. is mainly used as a tasty addition to dishes and juices due to its aromatic and nutritional properties. The plant has many biological and pharmacological effects that require deeper evaluation. In this study, anticancer, antioxidant, and antimicrobial activities of ethanol, ethanol/water extracts, and juice from C. aromaticus leaves were evaluated. Methods: (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) MTT assay, DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate)), molybdenum reducing power assay, and broth microdilution technique were used, respectively. Additionally, total phenolic (TPC) and total flavonoid content (TFC) with basic phytochemical composition of volatile compounds by GC-MS and GC-FID were assessed. Results: The results indicate that the strongest anticancer activity was provided by the ethanol extract with IC50 values of 4.94 ± 0.48 and 24.99 ± 1.80 µg/mL on human gastric AGS cells and human colorectal HCT 116 cells, respectively. The antioxidant potential was also the highest for the ethanol extract with IC50 values of 13.34 ± 0.11 (ABTS), 22.90 ± 1.30 (DPPH), and 290.17 ± 4.23 µg/mL (molybdenum reducing power). Antimicrobial experiments revealed that ethanol and ethanol/water extracts were the most potent on Clostridium perfringens (MIC value was <0.02 mg/mL). Phytochemical analysis showed a significant content of phenolic and flavonoid compounds in the ethanol extract (75.87 ± 0.96 mg gallic acid equivalent/g dry extract and 176.01 ± 3.58 mg quercetin equivalent/g dry extract, respectively). Furthermore, all the extracts contained carvacrol (49.09, 28.15, and 25.68% of volatile fraction in ethanol, ethanol/water extracts and juice, respectively). Camphor and oleamide were also detected in large quantity. Conclusions: C. aromaticus can be considered as a potential agent in the prevention and treatment of gastrointestinal cancers, especially the ethanol extract from the plant leaves due to its strong anticancer and antioxidant properties.
Related Topics
Concepts
Phytochemical
Antimicrobial
Gallic acid
DPPH
Flavonoid
Chemistry
Quercetin
Coleus
ABTS
Traditional medicine
Antioxidant
Food science
Ethanol
Broth microdilution
IC50
Polyphenol
MTT assay
Biochemistry
Carica
Hepatoprotection
Medicinal plants
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph18111756
- OA Status
- gold
- References
- 64
- OpenAlex ID
- https://openalex.org/W7105916398
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7105916398Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ph18111756Digital Object Identifier
- Title
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Coleus aromaticus Benth.—A Plant with Strong Anticancer and Antioxidant Potential In VitroWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-11-18Full publication date if available
- Authors
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Justyna Stefanowicz-Hajduk, Anna Hering, Rafał Hałasa, Szymon Masiak, Karolina Turczyn, J. Renata Ochocka, Monika Asztemborska, Szymon Masiak, Karolina TurczynList of authors in order
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https://doi.org/10.3390/ph18111756Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/ph18111756Direct OA link when available
- Concepts
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Phytochemical, Antimicrobial, Gallic acid, DPPH, Flavonoid, Chemistry, Quercetin, Coleus, ABTS, Traditional medicine, Antioxidant, Food science, Ethanol, Broth microdilution, IC50, Polyphenol, MTT assay, Biochemistry, Carica, Hepatoprotection, Medicinal plantsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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64Number of works referenced by this work
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