Combination of an Optically Induced Dielectrophoresis (ODEP) Mechanism and a Laminar Flow Pattern in a Microfluidic System for the Continuous Size-Based Sorting and Separation of Microparticles Article Swipe
Po-Yu Chu
,
Ai-Yun Wu
,
Kun-Yu Tsai
,
Chia‐Hsun Hsieh
,
Min‐Hsien Wu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/bios14060297
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/bios14060297
Optically induced dielectrophoresis (ODEP)-based microparticle sorting and separation is regarded as promising. However, current methods normally lack the downstream process for the transportation and collection of separated microparticles, which could limit its applications. To address this issue, an ODEP microfluidic chip encompassing three microchannels that join only at the central part of the microchannels (i.e., the working zone) was designed. During operation, three laminar flows were generated in the zone, where two dynamic light bar arrays were designed to sort and separate PS (polystyrene) microbeads of different sizes in a continuous manner. The separated PS microbeads were then continuously transported in laminar flows in a partition manner for the final collection. The results revealed that the method was capable of sorting and separating PS microbeads in a high-purity manner (e.g., the microbead purity values were 89.9 ± 3.7, 88.0 ± 2.5, and 92.8 ± 6.5% for the 5.8, 10.8, and 15.8 μm microbeads harvested, respectively). Overall, this study demonstrated the use of laminar flow and ODEP to achieve size-based sorting, separation, and collection of microparticles in a continuous and high-performance manner. Apart from the demonstration, this method can also be utilized for size-based sorting and the separation of other biological or nonbiological microparticles.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/bios14060297
- https://www.mdpi.com/2079-6374/14/6/297/pdf?version=1717667367
- OA Status
- gold
- Cited By
- 3
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399389138
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399389138Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/bios14060297Digital Object Identifier
- Title
-
Combination of an Optically Induced Dielectrophoresis (ODEP) Mechanism and a Laminar Flow Pattern in a Microfluidic System for the Continuous Size-Based Sorting and Separation of MicroparticlesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-06Full publication date if available
- Authors
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Po-Yu Chu, Ai-Yun Wu, Kun-Yu Tsai, Chia‐Hsun Hsieh, Min‐Hsien WuList of authors in order
- Landing page
-
https://doi.org/10.3390/bios14060297Publisher landing page
- PDF URL
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https://www.mdpi.com/2079-6374/14/6/297/pdf?version=1717667367Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2079-6374/14/6/297/pdf?version=1717667367Direct OA link when available
- Concepts
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Microfluidics, Laminar flow, Sorting, Dielectrophoresis, Microbead (research), Microparticle, Materials science, Nanotechnology, Microsphere, Chemistry, Computer science, Chemical engineering, Mechanics, Engineering, Programming language, Physics, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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