Combinatorial Fusion Rules to Describe Codon Assignment in the Standard Genetic Code Article Swipe
Alexander Nesterov‐Mueller
,
Roman S. Popov
,
Hervé Seligmann
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/life11010004
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/life11010004
We propose combinatorial fusion rules that describe the codon assignment in the standard genetic code simply and uniformly for all canonical amino acids. These rules become obvious if the origin of the standard genetic code is considered as a result of a fusion of four protocodes: Two dominant AU and GC protocodes and two recessive AU and GC protocodes. The biochemical meaning of the fusion rules consists of retaining the complementarity between cognate codons of the small hydrophobic amino acids and large charged or polar amino acids within the protocodes. The proto tRNAs were assembled in form of two kissing hairpins with 9-base and 10-base loops in the case of dominant protocodes and two 9-base loops in the case of recessive protocodes. The fusion rules reveal the connection between the stop codons, the non-canonical amino acids, pyrrolysine and selenocysteine, and deviations in the translation of mitochondria. Using fusion rules, we predicted the existence of additional amino acids that are essential for the development of the standard genetic code. The validity of the proposed partition of the genetic code into dominant and recessive protocodes is considered referring to state-of-the-art hypotheses. The formation of two aminoacyl-tRNA synthetase classes is compatible with four-protocode partition.
Related Topics
Concepts
Genetic code
Selenocysteine
Amino acid
Fusion
Stop codon
Genetics
Transfer RNA
Biology
Computational biology
Gene
Biochemistry
RNA
Enzyme
Cysteine
Linguistics
Philosophy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/life11010004
- https://www.mdpi.com/2075-1729/11/1/4/pdf?version=1609642864
- OA Status
- gold
- Cited By
- 3
- References
- 95
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3118052836
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3118052836Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/life11010004Digital Object Identifier
- Title
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Combinatorial Fusion Rules to Describe Codon Assignment in the Standard Genetic CodeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-12-23Full publication date if available
- Authors
-
Alexander Nesterov‐Mueller, Roman S. Popov, Hervé SeligmannList of authors in order
- Landing page
-
https://doi.org/10.3390/life11010004Publisher landing page
- PDF URL
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https://www.mdpi.com/2075-1729/11/1/4/pdf?version=1609642864Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2075-1729/11/1/4/pdf?version=1609642864Direct OA link when available
- Concepts
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Genetic code, Selenocysteine, Amino acid, Fusion, Stop codon, Genetics, Transfer RNA, Biology, Computational biology, Gene, Biochemistry, RNA, Enzyme, Cysteine, Linguistics, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2023: 1, 2021: 2Per-year citation counts (last 5 years)
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95Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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