Combined abiraterone acetate plus prednisone, salvage prostate bed radiotherapy and LH-RH agonists (CARLHA-GEP12) in biochemically-relapsing prostate cancer patients following prostatectomy: A phase I study of the GETUG/GEP Article Swipe

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S. Supiot , L. Campion , P. Pommier , Mélanie Doré , Clément Palpacuer , S. Racadot , Emmanuel Rio , G. Milano , Céline Mahier - Aït Oukhatar , C. Carrié ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.18632/oncotarget.25189

When AA was administered without goserilin, only 78% achieved castration levels. AA combined with SRT and goserilin did not increase pelvic toxicity, but lead to an unsuspected high frequency of grade 3 liver toxicity. The phase II recommended dose of AA combined to goserelin and SRT is 750 mg.

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Concepts

Medicine Prostate cancer Goserelin Urology Abiraterone acetate Prostatectomy Antiandrogen Prednisone Toxicity Cabazitaxel Androgen deprivation therapy Testosterone (patch) Castration Internal medicine Cancer Hormone

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Type: article
Language: en
Landing Page: https://doi.org/10.18632/oncotarget.25189
PDF: https://www.oncotarget.com/article/25189/pdf/
OA Status: diamond
Cited By: 13
References: 31
Related Works: 10
OpenAlex ID: https://openalex.org/W2801903900

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DOI: https://doi.org/10.18632/oncotarget.25189

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Title: Combined abiraterone acetate plus prednisone, salvage prostate bed radiotherapy and LH-RH agonists (CARLHA-GEP12) in biochemically-relapsing prostate cancer patients following prostatectomy: A phase I study of the GETUG/GEP

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Type: article

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Language: en

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Publication year: 2018

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Publication date: 2018-04-24

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Authors: S. Supiot, L. Campion, P. Pommier, Mélanie Doré, Clément Palpacuer, S. Racadot, Emmanuel Rio, G. Milano, Céline Mahier - Aït Oukhatar, C. Carrié

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Landing page: https://doi.org/10.18632/oncotarget.25189

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PDF URL: https://www.oncotarget.com/article/25189/pdf/

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Concepts: Medicine, Prostate cancer, Goserelin, Urology, Abiraterone acetate, Prostatectomy, Antiandrogen, Prednisone, Toxicity, Cabazitaxel, Androgen deprivation therapy, Testosterone (patch), Castration, Internal medicine, Cancer, Hormone

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Cited by: 13

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Citations by year (recent): 2024: 1, 2023: 1, 2022: 2, 2021: 4, 2020: 3

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References (count): 31

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Related works (count): 10

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