Combined analysis of albumin in situ hybridisation and C reactive protein immunohistochemistry for the diagnosis of intrahepatic cholangiocarcinoma: towards a molecular classification paradigm Article Swipe
Thomas Albrecht
,
Annik Rossberg
,
Fabian Rose
,
Kai Breuhahn
,
Eva-Marie Baumann
,
Marcell Tóth
,
Fritz Brinkmann
,
Alphonse Charbel
,
Monika Vogel
,
Bruno Köhler
,
Arianeb Mehrabi
,
Markus W. Büchler
,
Stephan Singer
,
Wiebke Solaß
,
Beate K. Straub
,
Peter Schirmacher
,
Stéphanie Roessler
,
Benjamin Goeppert
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/jcp-2024-209429
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/jcp-2024-209429
Aims Intrahepatic cholangiocarcinoma (iCCA) is a diagnosis of exclusion that can pose a challenge to the pathologist despite thorough clinical workup. Although several immunohistochemical markers have been proposed for iCCA, none of them reached clinical practice. We here assessed the combined usage of two promising diagnostic approaches, albumin in situ hybridisation (Alb-ISH) and C reactive protein (CRP) immunohistochemistry, for distinguishing iCCA from other adenocarcinoma primaries. Methods We conducted Alb-ISH and CRP immunohistochemistry in a large European iCCA cohort (n=153) and compared the results with a spectrum of other glandular adenocarcinomas of different origin (n=885). In addition, we correlated expression patterns with clinicopathological information and mutation data. Results Alb-ISH was highly specific for iCCA (specificity 98.8%) with almost complete negativity in perihilar CCA and only rare positives among other adenocarcinomas (sensitivity 69.5%). CRP identified the vast majority of iCCA cases (sensitivity 84.1%) at a lower specificity of 86.4%. Strikingly, the combination of CRP and Alb-ISH boosted the diagnostic sensitivity to 88.0% while retaining a considerable specificity of 86.1%. Alb-ISH significantly correlated with CRP expression, specific tumour morphologies and small or large duct iCCA subtypes. Neither Alb-ISH nor CRP was associated with iCCA patient survival. 16 of 17 recurrent mutations in either IDH1, IDH2 and FGFR2 affected Alb-ISH positive cases, while the only KRAS mutation corresponded to an Alb-ISH negative case. Conclusions In conclusion, we propose a sequential diagnostic approach for iCCA, integrating CRP immunohistochemistry and Alb-ISH. This may improve the accuracy of CCA classification and pave the way towards a molecular-guided CCA classification.
Related Topics
Concepts
Immunohistochemistry
Intrahepatic Cholangiocarcinoma
KRAS
Pathology
In situ hybridization
IDH1
Medicine
Internal medicine
Biology
Cancer
Mutation
Messenger RNA
Gene
Genetics
Colorectal cancer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/jcp-2024-209429
- https://jcp.bmj.com/content/jclinpath/early/2024/05/14/jcp-2024-209429.full.pdf
- OA Status
- hybrid
- Cited By
- 6
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396919651
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396919651Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/jcp-2024-209429Digital Object Identifier
- Title
-
Combined analysis of albumin in situ hybridisation and C reactive protein immunohistochemistry for the diagnosis of intrahepatic cholangiocarcinoma: towards a molecular classification paradigmWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-15Full publication date if available
- Authors
-
Thomas Albrecht, Annik Rossberg, Fabian Rose, Kai Breuhahn, Eva-Marie Baumann, Marcell Tóth, Fritz Brinkmann, Alphonse Charbel, Monika Vogel, Bruno Köhler, Arianeb Mehrabi, Markus W. Büchler, Stephan Singer, Wiebke Solaß, Beate K. Straub, Peter Schirmacher, Stéphanie Roessler, Benjamin GoeppertList of authors in order
- Landing page
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https://doi.org/10.1136/jcp-2024-209429Publisher landing page
- PDF URL
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https://jcp.bmj.com/content/jclinpath/early/2024/05/14/jcp-2024-209429.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
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https://jcp.bmj.com/content/jclinpath/early/2024/05/14/jcp-2024-209429.full.pdfDirect OA link when available
- Concepts
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Immunohistochemistry, Intrahepatic Cholangiocarcinoma, KRAS, Pathology, In situ hybridization, IDH1, Medicine, Internal medicine, Biology, Cancer, Mutation, Messenger RNA, Gene, Genetics, Colorectal cancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
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2025: 5, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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25Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.patterns | 99 |
| abstract_inverted_index.positive | 206 |
| abstract_inverted_index.proposed | 27 |
| abstract_inverted_index.reactive | 54 |
| abstract_inverted_index.specific | 110, 173 |
| abstract_inverted_index.spectrum | 85 |
| abstract_inverted_index.thorough | 18 |
| abstract_inverted_index.(Alb-ISH) | 51 |
| abstract_inverted_index.addition, | 95 |
| abstract_inverted_index.challenge | 13 |
| abstract_inverted_index.conducted | 67 |
| abstract_inverted_index.diagnosis | 6 |
| abstract_inverted_index.different | 91 |
| abstract_inverted_index.exclusion | 8 |
| abstract_inverted_index.glandular | 88 |
| abstract_inverted_index.mutations | 197 |
| abstract_inverted_index.perihilar | 120 |
| abstract_inverted_index.positives | 125 |
| abstract_inverted_index.practice. | 35 |
| abstract_inverted_index.promising | 44 |
| abstract_inverted_index.recurrent | 196 |
| abstract_inverted_index.retaining | 161 |
| abstract_inverted_index.subtypes. | 182 |
| abstract_inverted_index.survival. | 192 |
| abstract_inverted_index.associated | 188 |
| abstract_inverted_index.correlated | 97, 169 |
| abstract_inverted_index.diagnostic | 45, 156, 226 |
| abstract_inverted_index.expression | 98 |
| abstract_inverted_index.identified | 132 |
| abstract_inverted_index.negativity | 118 |
| abstract_inverted_index.primaries. | 64 |
| abstract_inverted_index.sequential | 225 |
| abstract_inverted_index.Conclusions | 219 |
| abstract_inverted_index.Strikingly, | 147 |
| abstract_inverted_index.approaches, | 46 |
| abstract_inverted_index.combination | 149 |
| abstract_inverted_index.conclusion, | 221 |
| abstract_inverted_index.expression, | 172 |
| abstract_inverted_index.information | 102 |
| abstract_inverted_index.integrating | 230 |
| abstract_inverted_index.pathologist | 16 |
| abstract_inverted_index.sensitivity | 157 |
| abstract_inverted_index.specificity | 144, 164 |
| abstract_inverted_index.(sensitivity | 129, 139 |
| abstract_inverted_index.(specificity | 113 |
| abstract_inverted_index.Intrahepatic | 1 |
| abstract_inverted_index.considerable | 163 |
| abstract_inverted_index.corresponded | 213 |
| abstract_inverted_index.morphologies | 175 |
| abstract_inverted_index.hybridisation | 50 |
| abstract_inverted_index.significantly | 168 |
| abstract_inverted_index.adenocarcinoma | 63 |
| abstract_inverted_index.classification | 242 |
| abstract_inverted_index.distinguishing | 59 |
| abstract_inverted_index.adenocarcinomas | 89, 128 |
| abstract_inverted_index.classification. | 251 |
| abstract_inverted_index.molecular-guided | 249 |
| abstract_inverted_index.cholangiocarcinoma | 2 |
| abstract_inverted_index.clinicopathological | 101 |
| abstract_inverted_index.immunohistochemical | 23 |
| abstract_inverted_index.immunohistochemistry | 71, 232 |
| abstract_inverted_index.immunohistochemistry, | 57 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5018009312, https://openalex.org/A5027386073 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 18 |
| corresponding_institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966, https://openalex.org/I4210117394, https://openalex.org/I4210143707 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/10 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Reduced inequalities |
| citation_normalized_percentile.value | 0.95074463 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |