Combined CHK1 and PD-L1 blockade as a novel therapeutic strategy against stemness and immunosuppression in ovarian cancer Article Swipe
Mengqing Chen
,
Lin Huang
,
Mengna Zhu
,
Jing Cai
,
Feiquan Ying
,
Lin Liu
,
Wenhan Li
,
Si Sun
,
Yiping Wen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00262-025-04215-9
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00262-025-04215-9
Related Topics
Concepts
No concepts available.
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s00262-025-04215-9
- https://link.springer.com/content/pdf/10.1007/s00262-025-04215-9.pdf
- OA Status
- gold
- References
- 43
- OpenAlex ID
- https://openalex.org/W4415959251
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4415959251Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s00262-025-04215-9Digital Object Identifier
- Title
-
Combined CHK1 and PD-L1 blockade as a novel therapeutic strategy against stemness and immunosuppression in ovarian cancerWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-06Full publication date if available
- Authors
-
Mengqing Chen, Lin Huang, Mengna Zhu, Jing Cai, Feiquan Ying, Lin Liu, Wenhan Li, Si Sun, Yiping WenList of authors in order
- Landing page
-
https://doi.org/10.1007/s00262-025-04215-9Publisher landing page
- PDF URL
-
https://link.springer.com/content/pdf/10.1007/s00262-025-04215-9.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://link.springer.com/content/pdf/10.1007/s00262-025-04215-9.pdfDirect OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
43Number of works referenced by this work
Full payload
| id | https://openalex.org/W4415959251 |
|---|---|
| doi | https://doi.org/10.1007/s00262-025-04215-9 |
| ids.doi | https://doi.org/10.1007/s00262-025-04215-9 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41196428 |
| ids.openalex | https://openalex.org/W4415959251 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | Q000037 |
| mesh[0].descriptor_ui | D000071877 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | antagonists & inhibitors |
| mesh[0].descriptor_name | Checkpoint Kinase 1 |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D000071877 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Checkpoint Kinase 1 |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D005260 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Female |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000818 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Animals |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D006801 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Humans |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D051379 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Mice |
| mesh[6].qualifier_ui | Q000187 |
| mesh[6].descriptor_ui | D014411 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | drug effects |
| mesh[6].descriptor_name | Neoplastic Stem Cells |
| mesh[7].qualifier_ui | Q000276 |
| mesh[7].descriptor_ui | D014411 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | immunology |
| mesh[7].descriptor_name | Neoplastic Stem Cells |
| mesh[8].qualifier_ui | Q000473 |
| mesh[8].descriptor_ui | D014411 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | pathology |
| mesh[8].descriptor_name | Neoplastic Stem Cells |
| mesh[9].qualifier_ui | Q000188 |
| mesh[9].descriptor_ui | D010051 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | drug therapy |
| mesh[9].descriptor_name | Ovarian Neoplasms |
| mesh[10].qualifier_ui | Q000276 |
| mesh[10].descriptor_ui | D010051 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | immunology |
| mesh[10].descriptor_name | Ovarian Neoplasms |
| mesh[11].qualifier_ui | Q000473 |
| mesh[11].descriptor_ui | D010051 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | pathology |
| mesh[11].descriptor_name | Ovarian Neoplasms |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D010051 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Ovarian Neoplasms |
| mesh[13].qualifier_ui | Q000037 |
| mesh[13].descriptor_ui | D060890 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | antagonists & inhibitors |
| mesh[13].descriptor_name | B7-H1 Antigen |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D060890 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | B7-H1 Antigen |
| mesh[15].qualifier_ui | Q000276 |
| mesh[15].descriptor_ui | D060890 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | immunology |
| mesh[15].descriptor_name | B7-H1 Antigen |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D023041 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Xenograft Model Antitumor Assays |
| mesh[17].qualifier_ui | Q000494 |
| mesh[17].descriptor_ui | D061067 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | pharmacology |
| mesh[17].descriptor_name | Antibodies, Monoclonal, Humanized |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D045744 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Cell Line, Tumor |
| mesh[19].qualifier_ui | Q000494 |
| mesh[19].descriptor_ui | D011719 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | pharmacology |
| mesh[19].descriptor_name | Pyrazines |
| mesh[20].qualifier_ui | Q000494 |
| mesh[20].descriptor_ui | D011720 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | pharmacology |
| mesh[20].descriptor_name | Pyrazoles |
| mesh[21].qualifier_ui | Q000494 |
| mesh[21].descriptor_ui | D000082082 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | pharmacology |
| mesh[21].descriptor_name | Immune Checkpoint Inhibitors |
| mesh[22].qualifier_ui | Q000494 |
| mesh[22].descriptor_ui | D000971 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | pharmacology |
| mesh[22].descriptor_name | Antineoplastic Combined Chemotherapy Protocols |
| mesh[23].qualifier_ui | Q000627 |
| mesh[23].descriptor_ui | D000971 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | therapeutic use |
| mesh[23].descriptor_name | Antineoplastic Combined Chemotherapy Protocols |
| mesh[24].qualifier_ui | Q000276 |
| mesh[24].descriptor_ui | D016246 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | immunology |
| mesh[24].descriptor_name | Lymphocytes, Tumor-Infiltrating |
| mesh[25].qualifier_ui | Q000187 |
| mesh[25].descriptor_ui | D016246 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | drug effects |
| mesh[25].descriptor_name | Lymphocytes, Tumor-Infiltrating |
| mesh[26].qualifier_ui | Q000037 |
| mesh[26].descriptor_ui | D000071877 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | antagonists & inhibitors |
| mesh[26].descriptor_name | Checkpoint Kinase 1 |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D000071877 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | Checkpoint Kinase 1 |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D005260 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Female |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D000818 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Animals |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D006801 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Humans |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D051379 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Mice |
| mesh[32].qualifier_ui | Q000187 |
| mesh[32].descriptor_ui | D014411 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | drug effects |
| mesh[32].descriptor_name | Neoplastic Stem Cells |
| mesh[33].qualifier_ui | Q000276 |
| mesh[33].descriptor_ui | D014411 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | immunology |
| mesh[33].descriptor_name | Neoplastic Stem Cells |
| mesh[34].qualifier_ui | Q000473 |
| mesh[34].descriptor_ui | D014411 |
| mesh[34].is_major_topic | True |
| mesh[34].qualifier_name | pathology |
| mesh[34].descriptor_name | Neoplastic Stem Cells |
| mesh[35].qualifier_ui | Q000188 |
| mesh[35].descriptor_ui | D010051 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | drug therapy |
| mesh[35].descriptor_name | Ovarian Neoplasms |
| mesh[36].qualifier_ui | Q000276 |
| mesh[36].descriptor_ui | D010051 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | immunology |
| mesh[36].descriptor_name | Ovarian Neoplasms |
| mesh[37].qualifier_ui | Q000473 |
| mesh[37].descriptor_ui | D010051 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | pathology |
| mesh[37].descriptor_name | Ovarian Neoplasms |
| mesh[38].qualifier_ui | Q000378 |
| mesh[38].descriptor_ui | D010051 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | metabolism |
| mesh[38].descriptor_name | Ovarian Neoplasms |
| mesh[39].qualifier_ui | Q000037 |
| mesh[39].descriptor_ui | D060890 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | antagonists & inhibitors |
| mesh[39].descriptor_name | B7-H1 Antigen |
| mesh[40].qualifier_ui | Q000378 |
| mesh[40].descriptor_ui | D060890 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | metabolism |
| mesh[40].descriptor_name | B7-H1 Antigen |
| mesh[41].qualifier_ui | Q000276 |
| mesh[41].descriptor_ui | D060890 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | immunology |
| mesh[41].descriptor_name | B7-H1 Antigen |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D023041 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Xenograft Model Antitumor Assays |
| mesh[43].qualifier_ui | Q000494 |
| mesh[43].descriptor_ui | D061067 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | pharmacology |
| mesh[43].descriptor_name | Antibodies, Monoclonal, Humanized |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D045744 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Cell Line, Tumor |
| mesh[45].qualifier_ui | Q000494 |
| mesh[45].descriptor_ui | D011719 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | pharmacology |
| mesh[45].descriptor_name | Pyrazines |
| mesh[46].qualifier_ui | Q000494 |
| mesh[46].descriptor_ui | D011720 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | pharmacology |
| mesh[46].descriptor_name | Pyrazoles |
| mesh[47].qualifier_ui | Q000494 |
| mesh[47].descriptor_ui | D000082082 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | pharmacology |
| mesh[47].descriptor_name | Immune Checkpoint Inhibitors |
| mesh[48].qualifier_ui | Q000494 |
| mesh[48].descriptor_ui | D000971 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | pharmacology |
| mesh[48].descriptor_name | Antineoplastic Combined Chemotherapy Protocols |
| mesh[49].qualifier_ui | Q000627 |
| mesh[49].descriptor_ui | D000971 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | therapeutic use |
| mesh[49].descriptor_name | Antineoplastic Combined Chemotherapy Protocols |
| type | article |
| title | Combined CHK1 and PD-L1 blockade as a novel therapeutic strategy against stemness and immunosuppression in ovarian cancer |
| biblio.issue | 12 |
| biblio.volume | 74 |
| biblio.last_page | 365 |
| biblio.first_page | 365 |
| is_xpac | False |
| apc_list.value | 3390 |
| apc_list.currency | EUR |
| apc_list.value_usd | 4390 |
| apc_paid.value | 3390 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 4390 |
| language | en |
| locations[0].id | doi:10.1007/s00262-025-04215-9 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S203303425 |
| locations[0].source.issn | 0340-7004, 1432-0851 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 0340-7004 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Cancer Immunology Immunotherapy |
| locations[0].source.host_organization | https://openalex.org/P4310319900 |
| locations[0].source.host_organization_name | Springer Science+Business Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319900 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://link.springer.com/content/pdf/10.1007/s00262-025-04215-9.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cancer Immunology, Immunotherapy |
| locations[0].landing_page_url | https://doi.org/10.1007/s00262-025-04215-9 |
| locations[1].id | pmid:41196428 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cancer immunology, immunotherapy : CII |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41196428 |
| locations[2].id | pmh:oai:europepmc.org:11401737 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12592612 |
| locations[3].id | pmh:oai:doaj.org/article:e44e58332e334d74b7fde1636de6ab40 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Cancer Immunology, Immunotherapy, Vol 74, Iss 12, Pp 1-15 (2025) |
| locations[3].landing_page_url | https://doaj.org/article/e44e58332e334d74b7fde1636de6ab40 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5067987782 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5576-2297 |
| authorships[0].author.display_name | Mengqing Chen |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210163933, https://openalex.org/I47720641 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[0].institutions[0].id | https://openalex.org/I47720641 |
| authorships[0].institutions[0].ror | https://ror.org/00p991c53 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I47720641 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Huazhong University of Science and Technology |
| authorships[0].institutions[1].id | https://openalex.org/I4210163933 |
| authorships[0].institutions[1].ror | https://ror.org/055gkcy74 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210163933 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Union Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Mengqing Chen |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[1].author.id | https://openalex.org/A5074327970 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-8254-7664 |
| authorships[1].author.display_name | Lin Huang |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210163933, https://openalex.org/I47720641 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[1].institutions[0].id | https://openalex.org/I47720641 |
| authorships[1].institutions[0].ror | https://ror.org/00p991c53 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I47720641 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Huazhong University of Science and Technology |
| authorships[1].institutions[1].id | https://openalex.org/I4210163933 |
| authorships[1].institutions[1].ror | https://ror.org/055gkcy74 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210163933 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Union Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Lin Huang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[2].author.id | https://openalex.org/A5114149005 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Mengna Zhu |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210163933, https://openalex.org/I47720641 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[2].institutions[0].id | https://openalex.org/I47720641 |
| authorships[2].institutions[0].ror | https://ror.org/00p991c53 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I47720641 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Huazhong University of Science and Technology |
| authorships[2].institutions[1].id | https://openalex.org/I4210163933 |
| authorships[2].institutions[1].ror | https://ror.org/055gkcy74 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210163933 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | Union Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Mengna Zhu |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[3].author.id | https://openalex.org/A5006758606 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-3609-4291 |
| authorships[3].author.display_name | Jing Cai |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210163933, https://openalex.org/I47720641 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[3].institutions[0].id | https://openalex.org/I47720641 |
| authorships[3].institutions[0].ror | https://ror.org/00p991c53 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I47720641 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Huazhong University of Science and Technology |
| authorships[3].institutions[1].id | https://openalex.org/I4210163933 |
| authorships[3].institutions[1].ror | https://ror.org/055gkcy74 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210163933 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Union Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jing Cai |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[4].author.id | https://openalex.org/A5033447038 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-2697-3604 |
| authorships[4].author.display_name | Feiquan Ying |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210163933, https://openalex.org/I47720641 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[4].institutions[0].id | https://openalex.org/I47720641 |
| authorships[4].institutions[0].ror | https://ror.org/00p991c53 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I47720641 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Huazhong University of Science and Technology |
| authorships[4].institutions[1].id | https://openalex.org/I4210163933 |
| authorships[4].institutions[1].ror | https://ror.org/055gkcy74 |
| authorships[4].institutions[1].type | healthcare |
| authorships[4].institutions[1].lineage | https://openalex.org/I4210163933 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | Union Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Feiquan Ying |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[5].author.id | https://openalex.org/A5076758946 |
| authorships[5].author.orcid | https://orcid.org/0009-0007-8329-5930 |
| authorships[5].author.display_name | Lin Liu |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210163933, https://openalex.org/I47720641 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[5].institutions[0].id | https://openalex.org/I47720641 |
| authorships[5].institutions[0].ror | https://ror.org/00p991c53 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I47720641 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Huazhong University of Science and Technology |
| authorships[5].institutions[1].id | https://openalex.org/I4210163933 |
| authorships[5].institutions[1].ror | https://ror.org/055gkcy74 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I4210163933 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | Union Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Lin Liu |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[6].author.id | https://openalex.org/A5014166660 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9412-1166 |
| authorships[6].author.display_name | Wenhan Li |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210163933, https://openalex.org/I47720641 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[6].institutions[0].id | https://openalex.org/I47720641 |
| authorships[6].institutions[0].ror | https://ror.org/00p991c53 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I47720641 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Huazhong University of Science and Technology |
| authorships[6].institutions[1].id | https://openalex.org/I4210163933 |
| authorships[6].institutions[1].ror | https://ror.org/055gkcy74 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210163933 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Union Hospital |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Wenhan Li |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[7].author.id | https://openalex.org/A5073681238 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8424-5763 |
| authorships[7].author.display_name | Si Sun |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210163933, https://openalex.org/I47720641 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[7].institutions[0].id | https://openalex.org/I47720641 |
| authorships[7].institutions[0].ror | https://ror.org/00p991c53 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I47720641 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Huazhong University of Science and Technology |
| authorships[7].institutions[1].id | https://openalex.org/I4210163933 |
| authorships[7].institutions[1].ror | https://ror.org/055gkcy74 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I4210163933 |
| authorships[7].institutions[1].country_code | CN |
| authorships[7].institutions[1].display_name | Union Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Si Sun |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[8].author.id | https://openalex.org/A5030193166 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Yiping Wen |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210163933, https://openalex.org/I47720641 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| authorships[8].institutions[0].id | https://openalex.org/I47720641 |
| authorships[8].institutions[0].ror | https://ror.org/00p991c53 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I47720641 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Huazhong University of Science and Technology |
| authorships[8].institutions[1].id | https://openalex.org/I4210163933 |
| authorships[8].institutions[1].ror | https://ror.org/055gkcy74 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I4210163933 |
| authorships[8].institutions[1].country_code | CN |
| authorships[8].institutions[1].display_name | Union Hospital |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Yiping Wen |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, 430022, Hubei, China |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://link.springer.com/content/pdf/10.1007/s00262-025-04215-9.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-11-06T00:00:00 |
| display_name | Combined CHK1 and PD-L1 blockade as a novel therapeutic strategy against stemness and immunosuppression in ovarian cancer |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-07T23:20:04.922697 |
| primary_topic | |
| cited_by_count | 0 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1007/s00262-025-04215-9 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S203303425 |
| best_oa_location.source.issn | 0340-7004, 1432-0851 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 0340-7004 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Cancer Immunology Immunotherapy |
| best_oa_location.source.host_organization | https://openalex.org/P4310319900 |
| best_oa_location.source.host_organization_name | Springer Science+Business Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319900 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://link.springer.com/content/pdf/10.1007/s00262-025-04215-9.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cancer Immunology, Immunotherapy |
| best_oa_location.landing_page_url | https://doi.org/10.1007/s00262-025-04215-9 |
| primary_location.id | doi:10.1007/s00262-025-04215-9 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S203303425 |
| primary_location.source.issn | 0340-7004, 1432-0851 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 0340-7004 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Cancer Immunology Immunotherapy |
| primary_location.source.host_organization | https://openalex.org/P4310319900 |
| primary_location.source.host_organization_name | Springer Science+Business Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319900 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://link.springer.com/content/pdf/10.1007/s00262-025-04215-9.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cancer Immunology, Immunotherapy |
| primary_location.landing_page_url | https://doi.org/10.1007/s00262-025-04215-9 |
| publication_date | 2025-11-06 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2807649309, https://openalex.org/W4393275890, https://openalex.org/W1967358345, https://openalex.org/W4410109705, https://openalex.org/W2138784667, https://openalex.org/W2907262475, https://openalex.org/W3152113071, https://openalex.org/W3089617720, https://openalex.org/W3063162426, https://openalex.org/W1594035260, https://openalex.org/W3112351255, https://openalex.org/W3170609854, https://openalex.org/W2072693879, https://openalex.org/W4294991252, https://openalex.org/W4412828732, https://openalex.org/W3186484195, https://openalex.org/W1997462426, https://openalex.org/W2227955965, https://openalex.org/W2053627244, https://openalex.org/W1977852856, https://openalex.org/W2160834915, https://openalex.org/W4390588778, https://openalex.org/W4366753692, https://openalex.org/W2915645504, https://openalex.org/W4393338151, https://openalex.org/W2783907570, https://openalex.org/W4302424483, https://openalex.org/W2605017029, https://openalex.org/W2602859993, https://openalex.org/W3069004765, https://openalex.org/W4399135115, https://openalex.org/W2047209914, https://openalex.org/W3039333879, https://openalex.org/W2982130750, https://openalex.org/W4324009728, https://openalex.org/W2154141161, https://openalex.org/W2140562572, https://openalex.org/W3022157481, https://openalex.org/W2565300642, https://openalex.org/W4391228864, https://openalex.org/W4399541065, https://openalex.org/W4409554754, https://openalex.org/W3139362637 |
| referenced_works_count | 43 |
| abstract_inverted_index | |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile |