Combined light and electron microscopy (CLEM) to quantify methamphetamine-induced alpha-synuclein-related pathology Article Swipe
Michela Ferrucci
,
Paola Lenzi
,
Gloria Lazzeri
,
Carla L. Busceti
,
Alessandro Frati
,
Stefano Puglisi‐Allegra
,
Francesco Fornai
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s00702-024-02741-x
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s00702-024-02741-x
Methamphetamine (METH) produces a cytopathology, which is rather specific within catecholamine neurons both in vitro and ex vivo, in animal models and chronic METH abusers. This led some authors to postulate a sort of parallelism between METH cytopathology and cell damage in Parkinson’s disease (PD). In fact, METH increases and aggregates alpha-syn proto-fibrils along with producing spreading of alpha-syn. Although alpha-syn is considered to be the major component of aggregates and inclusions developing within diseased catecholamine neurons including classic Lewy body (LB), at present, no study provided a quantitative assessment of this protein in situ, neither following METH nor in LB occurring in PD. Similarly, no study addressed the quantitative comparison between occurrence of alpha-syn and other key proteins and no investigation measured the protein compared with non-protein structure within catecholamine cytopathology. Therefore, the present study addresses these issues using an oversimplified model consisting of a catecholamine cell line where the novel approach of combined light and electron microscopy (CLEM) was used measuring the amount of alpha-syn, which is lower compared with p62 or poly-ubiquitin within pathological cell domains. The scenario provided by electron microscopy reveals unexpected findings, which are similar to those recently described in the pathology of PD featuring packing of autophagosome-like vesicles and key proteins shuttling autophagy substrates. Remarkably, small seed-like areas, densely packed with p62 molecules attached to poly-ubiquitin within wide vesicular domains occurred. The present data shed new light about quantitative morphometry of catecholamine cell damage in PD and within the addicted brain.
Related Topics
Concepts
Alpha-synuclein
Electron microscope
Cytopathology
Cell biology
Meth-
Biology
Lewy body
Pathology
Chemistry
Parkinson's disease
Medicine
Disease
Physics
Optics
Monomer
Acrylate
Cytology
Organic chemistry
Polymer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s00702-024-02741-x
- https://link.springer.com/content/pdf/10.1007/s00702-024-02741-x.pdf
- OA Status
- hybrid
- Cited By
- 5
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391896942
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391896942Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s00702-024-02741-xDigital Object Identifier
- Title
-
Combined light and electron microscopy (CLEM) to quantify methamphetamine-induced alpha-synuclein-related pathologyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-17Full publication date if available
- Authors
-
Michela Ferrucci, Paola Lenzi, Gloria Lazzeri, Carla L. Busceti, Alessandro Frati, Stefano Puglisi‐Allegra, Francesco FornaiList of authors in order
- Landing page
-
https://doi.org/10.1007/s00702-024-02741-xPublisher landing page
- PDF URL
-
https://link.springer.com/content/pdf/10.1007/s00702-024-02741-x.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://link.springer.com/content/pdf/10.1007/s00702-024-02741-x.pdfDirect OA link when available
- Concepts
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Alpha-synuclein, Electron microscope, Cytopathology, Cell biology, Meth-, Biology, Lewy body, Pathology, Chemistry, Parkinson's disease, Medicine, Disease, Physics, Optics, Monomer, Acrylate, Cytology, Organic chemistry, PolymerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.where | 150 |
| abstract_inverted_index.which | 6, 168, 189 |
| abstract_inverted_index.(CLEM) | 160 |
| abstract_inverted_index.(METH) | 2 |
| abstract_inverted_index.amount | 165 |
| abstract_inverted_index.animal | 20 |
| abstract_inverted_index.areas, | 215 |
| abstract_inverted_index.brain. | 248 |
| abstract_inverted_index.damage | 41, 241 |
| abstract_inverted_index.issues | 139 |
| abstract_inverted_index.models | 21 |
| abstract_inverted_index.packed | 217 |
| abstract_inverted_index.rather | 8 |
| abstract_inverted_index.within | 10, 74, 130, 176, 224, 245 |
| abstract_inverted_index.authors | 29 |
| abstract_inverted_index.between | 36, 112 |
| abstract_inverted_index.chronic | 23 |
| abstract_inverted_index.classic | 79 |
| abstract_inverted_index.densely | 216 |
| abstract_inverted_index.disease | 44 |
| abstract_inverted_index.domains | 227 |
| abstract_inverted_index.neither | 96 |
| abstract_inverted_index.neurons | 12, 77 |
| abstract_inverted_index.packing | 202 |
| abstract_inverted_index.present | 135, 230 |
| abstract_inverted_index.protein | 93, 125 |
| abstract_inverted_index.reveals | 186 |
| abstract_inverted_index.similar | 191 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Although | 60 |
| abstract_inverted_index.abusers. | 25 |
| abstract_inverted_index.addicted | 247 |
| abstract_inverted_index.approach | 153 |
| abstract_inverted_index.attached | 221 |
| abstract_inverted_index.combined | 155 |
| abstract_inverted_index.compared | 126, 171 |
| abstract_inverted_index.diseased | 75 |
| abstract_inverted_index.domains. | 179 |
| abstract_inverted_index.electron | 158, 184 |
| abstract_inverted_index.measured | 123 |
| abstract_inverted_index.present, | 84 |
| abstract_inverted_index.produces | 3 |
| abstract_inverted_index.proteins | 119, 208 |
| abstract_inverted_index.provided | 87, 182 |
| abstract_inverted_index.recently | 194 |
| abstract_inverted_index.scenario | 181 |
| abstract_inverted_index.specific | 9 |
| abstract_inverted_index.vesicles | 205 |
| abstract_inverted_index.addressed | 108 |
| abstract_inverted_index.addresses | 137 |
| abstract_inverted_index.alpha-syn | 52, 61, 115 |
| abstract_inverted_index.autophagy | 210 |
| abstract_inverted_index.component | 68 |
| abstract_inverted_index.described | 195 |
| abstract_inverted_index.featuring | 201 |
| abstract_inverted_index.findings, | 188 |
| abstract_inverted_index.following | 97 |
| abstract_inverted_index.including | 78 |
| abstract_inverted_index.increases | 49 |
| abstract_inverted_index.measuring | 163 |
| abstract_inverted_index.molecules | 220 |
| abstract_inverted_index.occurred. | 228 |
| abstract_inverted_index.occurring | 102 |
| abstract_inverted_index.pathology | 198 |
| abstract_inverted_index.postulate | 31 |
| abstract_inverted_index.producing | 56 |
| abstract_inverted_index.seed-like | 214 |
| abstract_inverted_index.shuttling | 209 |
| abstract_inverted_index.spreading | 57 |
| abstract_inverted_index.structure | 129 |
| abstract_inverted_index.vesicular | 226 |
| abstract_inverted_index.Similarly, | 105 |
| abstract_inverted_index.Therefore, | 133 |
| abstract_inverted_index.aggregates | 51, 70 |
| abstract_inverted_index.alpha-syn, | 167 |
| abstract_inverted_index.alpha-syn. | 59 |
| abstract_inverted_index.assessment | 90 |
| abstract_inverted_index.comparison | 111 |
| abstract_inverted_index.considered | 63 |
| abstract_inverted_index.consisting | 144 |
| abstract_inverted_index.developing | 73 |
| abstract_inverted_index.inclusions | 72 |
| abstract_inverted_index.microscopy | 159, 185 |
| abstract_inverted_index.occurrence | 113 |
| abstract_inverted_index.unexpected | 187 |
| abstract_inverted_index.Remarkably, | 212 |
| abstract_inverted_index.morphometry | 237 |
| abstract_inverted_index.non-protein | 128 |
| abstract_inverted_index.parallelism | 35 |
| abstract_inverted_index.substrates. | 211 |
| abstract_inverted_index.pathological | 177 |
| abstract_inverted_index.quantitative | 89, 110, 236 |
| abstract_inverted_index.Parkinson’s | 43 |
| abstract_inverted_index.catecholamine | 11, 76, 131, 147, 239 |
| abstract_inverted_index.cytopathology | 38 |
| abstract_inverted_index.investigation | 122 |
| abstract_inverted_index.proto-fibrils | 53 |
| abstract_inverted_index.cytopathology, | 5 |
| abstract_inverted_index.cytopathology. | 132 |
| abstract_inverted_index.oversimplified | 142 |
| abstract_inverted_index.poly-ubiquitin | 175, 223 |
| abstract_inverted_index.Methamphetamine | 1 |
| abstract_inverted_index.autophagosome-like | 204 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5400000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.88781282 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |