Combined Treatment with Evogliptin and Temozolomide Alters miRNA Expression but Shows Limited Additive Effect on Glioma Article Swipe
Seung Yoon Song
,
Keun Soo Lee
,
Jung-Eun Lee
,
Ju Won Ahn
,
Jaejoon Lim
,
Seung-Ho Yang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26199508
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26199508
Dipeptidyl-peptidase IV (DPP4) inhibitors have shown potential anti-tumor properties. This study investigates the therapeutic potential of evogliptin, a DPP4 inhibitor, both as a single agent and in combination with temozolomide (TMZ), in glioma models. In vitro studies were performed using U87 and U373 glioma cell lines exposed to different concentrations of TMZ (250, 500 μM) and evogliptin (250, 500 ng/mL), either alone or together, for 24, 48, and 72 h. Cell viability was determined with the MTT assay. In vivo effectiveness was tested in a xenograft mouse model treated with intraperitoneal injections of evogliptin (60 mg/k g/day), TMZ (15 mg/kg/day), or their combination over 3 weeks. The combination of TMZ and evogliptin markedly reduced cell viability compared to single-agent treatments. DPP4 mRNA levels decreased more substantially with combination therapy. miRNA expression profiling with Affymetrix arrays indicated that certain miRNAs, such as miR-4440 and miR-6780b-5p, were upregulated after treatment with evogliptin or the combination regimen, whereas others were downregulated. These miRNAs could play a role in limiting glioma growth through DPP4 regulation. In the animal model, evogliptin alone did not provide a survival advantage. Analysis of TCGA data showed that glioma patients with decreased DPP4 expression had improved survival rates. The co-administration of evogliptin and temozolomide resulted in distinct miRNA profile changes. Nevertheless, both in vitro and in vivo, the added cytotoxicity from the combination was minimal.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms26199508
- https://www.mdpi.com/1422-0067/26/19/9508/pdf?version=1759139054
- OA Status
- gold
- References
- 26
- OpenAlex ID
- https://openalex.org/W4414653285
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4414653285Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms26199508Digital Object Identifier
- Title
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Combined Treatment with Evogliptin and Temozolomide Alters miRNA Expression but Shows Limited Additive Effect on GliomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-09-28Full publication date if available
- Authors
-
Seung Yoon Song, Keun Soo Lee, Jung-Eun Lee, Ju Won Ahn, Jaejoon Lim, Seung-Ho YangList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms26199508Publisher landing page
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https://www.mdpi.com/1422-0067/26/19/9508/pdf?version=1759139054Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/26/19/9508/pdf?version=1759139054Direct OA link when available
- Cited by
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0Total citation count in OpenAlex
- References (count)
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26Number of works referenced by this work
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