Combining information to estimate adherence in studies of pre‐exposure prophylaxis for HIV prevention: Application to HPTN 067 Article Swipe
James P. Hughes
,
Brian D. Williamson
,
Chloe Krakauer
,
Gordon Chau
,
B Gutierrez Ortiz
,
Jon Wakefield
,
Craig W. Hendrix
,
K. Rivet Amico
,
Timothy H. Holtz
,
Linda‐Gail Bekker
,
Robert M. Grant
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/sim.9321
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/sim.9321
In trials of oral HIV pre‐exposure prophylaxis (PrEP), multiple approaches have been used to measure adherence, including self‐report, pill counts, electronic dose monitoring devices, and biological measures such as drug levels in plasma, peripheral blood mononuclear cells, hair, and/or dried blood spots. No one of these measures is ideal and each has strengths and weaknesses. However, accurate estimates of adherence to oral PrEP are important as drug efficacy is closely tied to adherence, and secondary analyses of trial data within identified adherent/non‐adherent subgroups may yield important insights into real‐world drug effectiveness. We develop a statistical approach to combining multiple measures of adherence and show in simulated data that the proposed method provides a more accurate measure of true adherence than self‐report. We then apply the method to estimate adherence in the ADAPT study (HPTN 067) in South African women.
Related Topics
Concepts
Pill
Human immunodeficiency virus (HIV)
Medicine
Pre-exposure prophylaxis
Strengths and weaknesses
Drug
Measure (data warehouse)
Clinical trial
Intensive care medicine
Immunology
Pharmacology
Internal medicine
Computer science
Data mining
Men who have sex with men
Psychology
Social psychology
Syphilis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/sim.9321
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sim.9321
- OA Status
- bronze
- Cited By
- 1
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210811016
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4210811016Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/sim.9321Digital Object Identifier
- Title
-
Combining information to estimate adherence in studies of pre‐exposure prophylaxis for HIV prevention: Application to HPTN 067Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-01-25Full publication date if available
- Authors
-
James P. Hughes, Brian D. Williamson, Chloe Krakauer, Gordon Chau, B Gutierrez Ortiz, Jon Wakefield, Craig W. Hendrix, K. Rivet Amico, Timothy H. Holtz, Linda‐Gail Bekker, Robert M. GrantList of authors in order
- Landing page
-
https://doi.org/10.1002/sim.9321Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sim.9321Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sim.9321Direct OA link when available
- Concepts
-
Pill, Human immunodeficiency virus (HIV), Medicine, Pre-exposure prophylaxis, Strengths and weaknesses, Drug, Measure (data warehouse), Clinical trial, Intensive care medicine, Immunology, Pharmacology, Internal medicine, Computer science, Data mining, Men who have sex with men, Psychology, Social psychology, SyphilisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
24Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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