Comorbid brain disorders associated with diabetes: therapeutic potentials of prebiotics, probiotics and herbal drugs Article Swipe
Ajit Kumar Thakur
,
Sakshi Tyagi
,
Nikhila Shekhar
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1186/s41231-019-0043-6
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1186/s41231-019-0043-6
Prevalence of diabetes and comorbid brain disorders is increasing worldwide particularly in low- and middle-income countries. Diabetes and its complications impose substantial economic costs on the developing countries. Several comorbid conditions have been described for diabetes including central nervous system (CNS) disorders. Molecular changes in CNS due to chronic hyperglycemia could be the root cause of psychiatric comorbidities in metabolic syndrome as dietary carbohydrates and proteins affect plasma concentrations of many neurotransmitters involved in brain function. Glucose metabolism play an important role related in neuroenergetics, neurotransmission, energy storage, biosynthesis and oxidative defense. Thus, tight regulation of glucose metabolism is critical for normal brain physiology. An exaggerated symptom of depression, anxiety, and cognitive deficits are shown in diabetic animal models as well as in a population-based studies. Several studies show that many of the CNS acting drugs affected the glucose homeostasis and modulate brain physiology apart from their primary pharmacological actions. Gut-microbiota involve in the modulation of various physiological and pathological conditions of metabolic disorders and mental health by influencing the regulation of energy balance and release of neurotransmitters. Presently, no specific pharmacotherapies are available for CNS comorbidities associated with diabetes. However, some prebiotics, probiotics and herbal drugs are playing promising role in management of these CNS complications. Therefore, the evidence-based studies through translational research and clinical setup are warranted for better understanding for the relationship between brain glucose homeostasis and CNS complication as well as development of poly-pharmacologically active therapeutic drugs for the management of comorbid disorders associated with diabetic patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s41231-019-0043-6
- https://transmedcomms.biomedcentral.com/track/pdf/10.1186/s41231-019-0043-6
- OA Status
- hybrid
- Cited By
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2963304075Canonical identifier for this work in OpenAlex
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https://doi.org/10.1186/s41231-019-0043-6Digital Object Identifier
- Title
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Comorbid brain disorders associated with diabetes: therapeutic potentials of prebiotics, probiotics and herbal drugsWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-07-19Full publication date if available
- Authors
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Ajit Kumar Thakur, Sakshi Tyagi, Nikhila ShekharList of authors in order
- Landing page
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https://doi.org/10.1186/s41231-019-0043-6Publisher landing page
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https://transmedcomms.biomedcentral.com/track/pdf/10.1186/s41231-019-0043-6Direct link to full text PDF
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hybridOpen access status per OpenAlex
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https://transmedcomms.biomedcentral.com/track/pdf/10.1186/s41231-019-0043-6Direct OA link when available
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Diabetes mellitus, Medicine, Glucose homeostasis, Energy homeostasis, Population, Bioinformatics, Gut flora, Insulin resistance, Internal medicine, Endocrinology, Biology, Obesity, Immunology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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23Total citation count in OpenAlex
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2025: 5, 2024: 4, 2023: 2, 2022: 4, 2021: 6Per-year citation counts (last 5 years)
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175Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2024099384, https://openalex.org/W2464084236, https://openalex.org/W2343344675, https://openalex.org/W2338167986, https://openalex.org/W1989674525, https://openalex.org/W2036269216, https://openalex.org/W1994844104, https://openalex.org/W2012197362, https://openalex.org/W1970102431, https://openalex.org/W2036284058, https://openalex.org/W2141567007, https://openalex.org/W2028999384, https://openalex.org/W2082162766, https://openalex.org/W2062989356, https://openalex.org/W2013952491, https://openalex.org/W2019616618, https://openalex.org/W1986668408, https://openalex.org/W2009833479, https://openalex.org/W2016093996, https://openalex.org/W2048893204, https://openalex.org/W2041158750, https://openalex.org/W2078118869, https://openalex.org/W2083252150, https://openalex.org/W2056267149, https://openalex.org/W2049175531, https://openalex.org/W2088864173, https://openalex.org/W6674726887, https://openalex.org/W2126407740, https://openalex.org/W2139359479, https://openalex.org/W2045924832, https://openalex.org/W2004241252, https://openalex.org/W2162096099, https://openalex.org/W2123385684, https://openalex.org/W1802558620, https://openalex.org/W2098323255, https://openalex.org/W2015990890, https://openalex.org/W2025723398, https://openalex.org/W2169887727, https://openalex.org/W2108933333, https://openalex.org/W4230270855, https://openalex.org/W2061770411, https://openalex.org/W2072219714, https://openalex.org/W4296336789, https://openalex.org/W2026240508, https://openalex.org/W1999490251, https://openalex.org/W1991473442, https://openalex.org/W1520292708, https://openalex.org/W1990195462, https://openalex.org/W2046667801, https://openalex.org/W2099039403, https://openalex.org/W2034170211, https://openalex.org/W2017760292, https://openalex.org/W1764171741, https://openalex.org/W2080312294, https://openalex.org/W2074289124, https://openalex.org/W2058717577, https://openalex.org/W1964374490, 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