Comparative Analysis of Aducanumab, Zagotenemab and Pioglitazone as Targeted Treatment Strategies for Alzheimer’s Disease Article Swipe
Morteza Abyadeh
,
Vivek Gupta
,
Veer Bala Gupta
,
Nitin Chitranshi
,
Yunqi Wu
,
Ardeshir Amirkhani
,
Anna Meyfour
,
Samran Sheriff
,
Ting Shen
,
Kunal Dhiman
,
Ghasem Hosseini Salekdeh
,
Paul A. Haynes
,
Stuart L. Graham
,
Mehdi Mirzaei
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.14336/ad.2021.0719
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.14336/ad.2021.0719
Alzheimer's disease (AD) is the leading cause of dementia that has remained a major medical, sociocultural and economical challenge globally. Previously developed treatments like anticholinesterase inhibitors (AChEIs) and N-methyl-D-aspartate receptor (NMDAR) antagonists only provide short-term symptomatic improvement and do not prevent progression. Repeated setbacks and failures over the past 25 years in AD clinical trials have hindered efforts to develop effective AD treatments. Fortunately, Aducanumab, a specific anti-amyloid β antibody, has shown promising clinical results and was recently approved by the Food and Drug Administration (FDA) through an accelerated approval pathway. This has raised hopes for AD patients; however post-approval trials are necessary to estimate the true scope of its clinical benefits. We have reviewed several AD clinical studies and summarized the experience to date with Aducanumab and two other potential AD drugs including Zagotenemab (an anti-tau antibody) and Pioglitazone (nuclear Peroxisome-Proliferator Activated Receptor γ (PPARγ) agonist). These have shown mixed results so far and the next few years will be critical to elucidate and interpret their broad long-term protective effects. A concerted effort is required to understand and strengthen the translation of pre-clinical findings from these drugs to routine clinical practice.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.14336/ad.2021.0719
- OA Status
- gold
- Cited By
- 59
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200518337
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4200518337Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.14336/ad.2021.0719Digital Object Identifier
- Title
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Comparative Analysis of Aducanumab, Zagotenemab and Pioglitazone as Targeted Treatment Strategies for Alzheimer’s DiseaseWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-01Full publication date if available
- Authors
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Morteza Abyadeh, Vivek Gupta, Veer Bala Gupta, Nitin Chitranshi, Yunqi Wu, Ardeshir Amirkhani, Anna Meyfour, Samran Sheriff, Ting Shen, Kunal Dhiman, Ghasem Hosseini Salekdeh, Paul A. Haynes, Stuart L. Graham, Mehdi MirzaeiList of authors in order
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https://doi.org/10.14336/ad.2021.0719Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.14336/ad.2021.0719Direct OA link when available
- Concepts
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Medicine, Clinical trial, Dementia, Disease, Pioglitazone, Intensive care medicine, Food and drug administration, Drug, Alzheimer's disease, Pharmacology, Bioinformatics, Internal medicine, Type 2 diabetes, Diabetes mellitus, Endocrinology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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59Total citation count in OpenAlex
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2025: 9, 2024: 13, 2023: 18, 2022: 18, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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83Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.remained | 11 |
| abstract_inverted_index.required | 175 |
| abstract_inverted_index.reviewed | 114 |
| abstract_inverted_index.setbacks | 43 |
| abstract_inverted_index.specific | 66 |
| abstract_inverted_index.Activated | 142 |
| abstract_inverted_index.agonist). | 146 |
| abstract_inverted_index.antibody) | 137 |
| abstract_inverted_index.antibody, | 69 |
| abstract_inverted_index.benefits. | 111 |
| abstract_inverted_index.challenge | 18 |
| abstract_inverted_index.concerted | 172 |
| abstract_inverted_index.developed | 21 |
| abstract_inverted_index.effective | 60 |
| abstract_inverted_index.elucidate | 163 |
| abstract_inverted_index.globally. | 19 |
| abstract_inverted_index.including | 133 |
| abstract_inverted_index.interpret | 165 |
| abstract_inverted_index.long-term | 168 |
| abstract_inverted_index.necessary | 102 |
| abstract_inverted_index.patients; | 97 |
| abstract_inverted_index.potential | 130 |
| abstract_inverted_index.practice. | 191 |
| abstract_inverted_index.promising | 72 |
| abstract_inverted_index.Aducanumab | 126 |
| abstract_inverted_index.Previously | 20 |
| abstract_inverted_index.economical | 17 |
| abstract_inverted_index.experience | 122 |
| abstract_inverted_index.inhibitors | 25 |
| abstract_inverted_index.protective | 169 |
| abstract_inverted_index.short-term | 34 |
| abstract_inverted_index.strengthen | 179 |
| abstract_inverted_index.summarized | 120 |
| abstract_inverted_index.treatments | 22 |
| abstract_inverted_index.understand | 177 |
| abstract_inverted_index.Aducanumab, | 64 |
| abstract_inverted_index.Alzheimer's | 0 |
| abstract_inverted_index.Zagotenemab | 134 |
| abstract_inverted_index.accelerated | 88 |
| abstract_inverted_index.antagonists | 31 |
| abstract_inverted_index.improvement | 36 |
| abstract_inverted_index.symptomatic | 35 |
| abstract_inverted_index.translation | 181 |
| abstract_inverted_index.treatments. | 62 |
| abstract_inverted_index.Fortunately, | 63 |
| abstract_inverted_index.Pioglitazone | 139 |
| abstract_inverted_index.anti-amyloid | 67 |
| abstract_inverted_index.pre-clinical | 183 |
| abstract_inverted_index.progression. | 41 |
| abstract_inverted_index.post-approval | 99 |
| abstract_inverted_index.sociocultural | 15 |
| abstract_inverted_index.Administration | 84 |
| abstract_inverted_index.anticholinesterase | 24 |
| abstract_inverted_index.N-methyl-D-aspartate | 28 |
| abstract_inverted_index.Peroxisome-Proliferator | 141 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 14 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.97446541 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |