Comparative analysis of changes in whey proteins of goat milk throughout the lactation cycle using quantitative proteomics Article Swipe
Xueheng Sun
,
Zhongna Yu
,
Chuozi Liang
,
Shubin Xie
,
Hexiang Wang
,
Jun Wang
,
Yongxin Yang
,
Rongwei Han
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3168/jds.2022-21800
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3168/jds.2022-21800
The composition and content of goat milk proteins are affected by many factors and have been extensively studied. However, variation in whey protein composition in goat milk throughout the lactation cycle has not been clarified. In the current study, 15 dairy goats were selected, and milk samples were collected at 1, 3, 30, 90, 150, and 240 d after delivery. Whey proteins were separated and digested and then identified using data-independent acquisition (DIA) and data-dependent acquisition proteomics approaches. Protein profiles identified using DIA were consistent with those of the data-dependent acquisition proteomics approach according to clustering and principal component analyses. Significant differences in the abundance of 238 proteins around the lactation cycle were identified using the DIA approach. Developmental changes of the whey proteome corresponding to lactation stage were revealed: plasminogen, α-2-macroglobulin, and fibronectin levels decreased from d 1 to 240, whereas polymeric immunoglobulin receptor, nucleobindin 2, fatty acid-binding protein 3, and lactoperoxidase increased from d 1 to 240. Protein-protein interaction analysis showed that fibronectin with a higher degree of connectivity is a central node. The findings are of great significance to better understanding the potential role of specific proteins and the mechanism of protein biosynthesis or intercellular transport in the mammary glands related to the physiological changes of dairy goats.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3168/jds.2022-21800
- http://www.journalofdairyscience.org/article/S0022030222006762/pdf
- OA Status
- gold
- Cited By
- 16
- References
- 51
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4309531934Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3168/jds.2022-21800Digital Object Identifier
- Title
-
Comparative analysis of changes in whey proteins of goat milk throughout the lactation cycle using quantitative proteomicsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-21Full publication date if available
- Authors
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Xueheng Sun, Zhongna Yu, Chuozi Liang, Shubin Xie, Hexiang Wang, Jun Wang, Yongxin Yang, Rongwei HanList of authors in order
- Landing page
-
https://doi.org/10.3168/jds.2022-21800Publisher landing page
- PDF URL
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https://www.journalofdairyscience.org/article/S0022030222006762/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.journalofdairyscience.org/article/S0022030222006762/pdfDirect OA link when available
- Concepts
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Lactation, Proteomics, Lactoperoxidase, Proteome, Whey protein, Biology, Chemistry, Food science, Biochemistry, Enzyme, Peroxidase, Gene, Pregnancy, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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16Total citation count in OpenAlex
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2025: 5, 2024: 9, 2023: 2Per-year citation counts (last 5 years)
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51Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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