Comparative analysis of the efficacy and functional recovery of unilateral biportal endoscopy-assisted lumbar interbody fusion for the treatment of lumbar disc herniation Article Swipe
Yunzhong Zhan
,
Fan Yang
,
Zhou Ye
,
Huafei Liu
,
Yichen Wu
,
Huang Weicheng
,
Yunzhong Zhan
,
Fan Yang
,
Zhou Ye
,
Huafei Liu
,
Yichen Wu
,
Huang Weicheng
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-25838-z
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-25838-z
This study aimed to evaluate the impact of unilateral biportal endoscopy (UBE) assisted interbody fusion on the functional recovery of patients diagnosed with lumbar disc herniation (LDH). From October 2021 to October 2022, 132 patients with LDH were selected as the research objects. The clinical data were retrospectively analyzed. According to the different surgical methods, LDH patients were divided into experimental group and control group (n = 66). The control group underwent conventional posterior lumbar open interbody fusion surgery, while the experimental group received interbody fusion surgery assisted by UBE. The clinical efficacy and perioperative indicators (operation time, total blood loss, 48 h postoperative drainage volume, and length of hospital stay) were recorded and compared between the two groups. The lumbar spine imaging parameters (lumbar lordosis index, posterior disc height, intervertebral space height, and Cobb Angle) before and after treatment were compared between the two groups. Lumbar function was evaluated using the Japanese Orthopedic Association (JOA) score, the Visual Analogue Scale (VAS), and the Oswestry Disability Index (ODI). Quality of life was assessed using the World Health Organization Quality of Life Scale (WHO-QOL-BREF). The incidence of complications after treatment was compared between the two groups. Multivariate logistic regression analysis was employed to identify influencing factors. In terms of low back pain improvement, the effective rate of the experimental group was 96.97%, which was significantly higher than 80.30% of the control group (P < 0.01). In terms of leg pain improvement, the effective rate of the experimental group was 95.45%, which was significantly higher than 75.76% of the control group (P < 0.01). The operation time and length of hospital stay in the experimental group were shorter than those in the control group (P < 0.001). The total blood loss and 48 h postoperative drainage volume in the experimental group were significantly less than those in the control group (P < 0.001). The lumbar lordosis index and posterior disc height of the two groups after operation were significantly higher than those before operation (P < 0.05). The intervertebral space height and Cobb Angle of the two groups after operation were significantly lower than those before operation (P < 0.05). The improvement of lumbar imaging parameters in the experimental group after operation was significantly better than that in the control group (P < 0.01). The JOA scores of the two groups after operation were significantly higher than those before operation, and the VAS scores of low back pain and leg pain and ODI scores were significantly lower than those before operation (P < 0.05). The improvement of the above indexes in the experimental group after operation was significantly better than that in the control group (P < 0.01). The incidence of complications in the experimental group was significantly lower than that in the control group (P < 0.01). The WHOQOL-BREF scores of the two groups after surgery were significantly higher than those before surgery (P < 0.05). The improvement of WHOQOL-BREF score in the experimental group after surgery was significantly better than that in the control group (P < 0.001). Multivariate Logistic regression analysis showed that UBE-assisted interbody fusion was an independent protective factor for good clinical efficacy in patients with LDH after adjusting the covariates of clinical symptom distribution, trauma history and Modic changes (P < 0.05). UBE interbody fusion has certain clinical advantages in the treatment of LDH. Compared with conventional open surgery, UBE interbody fusion has less bleeding and faster postoperative recovery. Moreover, UBE interbody fusion can relieve the symptoms of low back pain, promote the recovery of lumbar function and improve the quality of life. UBE interbody fusion is a safe and feasible choice in clinical treatment.
Related Topics
Concepts
Medicine
Surgery
Visual analogue scale
Oswestry Disability Index
Perioperative
Orthopedic surgery
Lumbar
Cobb angle
Spinal fusion
Low back pain
Lumbar vertebrae
Lordosis
Arthrodesis
Statistical significance
Back pain
Quality of life (healthcare)
Lumbar disc herniation
Anesthesia
Clinical efficacy
Incidence (geometry)
Retrospective cohort study
Intervertebral disc
Discectomy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-025-25838-z
- https://www.nature.com/articles/s41598-025-25838-z.pdf
- OA Status
- gold
- References
- 26
- OpenAlex ID
- https://openalex.org/W7106626159
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106626159Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-025-25838-zDigital Object Identifier
- Title
-
Comparative analysis of the efficacy and functional recovery of unilateral biportal endoscopy-assisted lumbar interbody fusion for the treatment of lumbar disc herniationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-25Full publication date if available
- Authors
-
Yunzhong Zhan, Fan Yang, Zhou Ye, Huafei Liu, Yichen Wu, Huang Weicheng, Yunzhong Zhan, Fan Yang, Zhou Ye, Huafei Liu, Yichen Wu, Huang WeichengList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-025-25838-zPublisher landing page
- PDF URL
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https://www.nature.com/articles/s41598-025-25838-z.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41598-025-25838-z.pdfDirect OA link when available
- Concepts
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Medicine, Surgery, Visual analogue scale, Oswestry Disability Index, Perioperative, Orthopedic surgery, Lumbar, Cobb angle, Spinal fusion, Low back pain, Lumbar vertebrae, Lordosis, Arthrodesis, Statistical significance, Back pain, Quality of life (healthcare), Lumbar disc herniation, Anesthesia, Clinical efficacy, Incidence (geometry), Retrospective cohort study, Intervertebral disc, DiscectomyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
26Number of works referenced by this work
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