Comparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O‐Glycan Degradation and Pathogenicity in a Potentially Multidrug‐Resistant Clostridium tertium Strain Article Swipe
Seonghun Kim
,
Ji-Young Kang
,
Jung sook Lee
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/mbo3.70169
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/mbo3.70169
Clostridium tertium is a pathogenic bacterium that directly colonizes the gastrointestinal mucosa, causing inflammation and neutropenia. The virulence factors and pathogenic mechanisms of C. tertium are not well known. In this study, C. tertium HGMC01 was isolated by enrichment culture of human feces, and its whole chromosome genome was sequenced without extra plasmids. C. tertium HGMC01 had a larger genome and a higher gene count compared with five other C. tertium strains. A pangenome analysis of six strains showed that C. tertium HGMC01 had the highest number of unique genes and the lowest number of accessory genes clustered phylogenetically with C. tertium src5, a strain of animal origin. C. tertium HGMC01 genome showed a variety of secreted glycoside hydrolases and carbohydrate‐binding modules for mucin O‐glycan degradation and sialic acid catabolism including sialidase and sialic acid transporter. These genes strongly suggested that the strain could interact the human gut cells through recognition or adhesion to mucin glycans. Moreover, various mobile genetic elements in its genome also indicated the genetic diversity and plasticity of the strain to gain virulence factors and antibiotic/multidrug‐resistant genes potentially acquired by horizontal gene transfer for the evolution of the pathogenicity. Additionally, experiments with human embryonic kidney cells revealed that components of C. tertium HGMC01 cell wall may play roles as virulence factors by modulating cytokine signaling pathways dependent on Toll‐like receptors. Overall, this comparative genomic analysis provides information about how C. tertium strains cause disease through mucin glycan degradation, colonization, multidrug resistance, and modulation of immune responses.
Related Topics
Concepts
Biology
Virulence
Comparative genomics
Gene
Genome
Genetics
Sialic acid
Mucin
Pathogenicity island
Microbiology
Genomic island
Strain (injury)
Genomics
Horizontal gene transfer
Whole genome sequencing
Sialidase
Glycan
Mobile genetic elements
Mutation
Immune system
Functional genomics
Genome evolution
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/mbo3.70169
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mbo3.70169
- OA Status
- gold
- References
- 67
- OpenAlex ID
- https://openalex.org/W7106584382
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106584382Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/mbo3.70169Digital Object Identifier
- Title
-
Comparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O‐Glycan Degradation and Pathogenicity in a Potentially Multidrug‐Resistant Clostridium tertium StrainWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-24Full publication date if available
- Authors
-
Seonghun Kim, Ji-Young Kang, Jung sook LeeList of authors in order
- Landing page
-
https://doi.org/10.1002/mbo3.70169Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mbo3.70169Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mbo3.70169Direct OA link when available
- Concepts
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Biology, Virulence, Comparative genomics, Gene, Genome, Genetics, Sialic acid, Mucin, Pathogenicity island, Microbiology, Genomic island, Strain (injury), Genomics, Horizontal gene transfer, Whole genome sequencing, Sialidase, Glycan, Mobile genetic elements, Mutation, Immune system, Functional genomics, Genome evolutionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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67Number of works referenced by this work
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