Comparative investigation of aerial part and root in Lamiophlomis rotata using UPLC-Q-Orbitrap-MS coupled with chemometrics Article Swipe
Tong Li
,
Jia Li
,
Ruijiao Du
,
Chengjuan Liu
,
Shengjie Huang
,
Heshui Yu
,
Lifeng Han
,
Xiaopeng Chen
,
Yuefei Wang
,
Miaomiao Jiang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.arabjc.2022.103740
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.arabjc.2022.103740
Lamiophlomis rotata (Benth.) Kudo (L. rotata) belongs to Lamiaceae family, which is an important medicinal plant endemic to Qinghai Tibet Plateau. Traditionally, the whole herb of L. rotata is used for medicine, especially for the treatment of rheumatoid arthritis (RA) in clinical practise. As a result of absolute digging, the plant has a long regeneration cycle after excavation and the damage to plateau grassland ecological environment is difficult to recover. It has been encouraged to use aerial part of the plant with the purpose of protecting environment and maintaning biological diversity. At present, researchers have compared the primary metabolites and iridoids between aerial parts and roots, but there are few reports on the chemical differences and activity comparison of secondary metabolites. In order to characterize the secondary metabolites of different parts, UPLC/Q-Orbitrap-MS was employed to collect data from the extracts of aerial parts and roots, in combination with plant metabolomics technology to screen and quantify differential metabolites. At the same time, network pharmacological analysis with rheumatoid arthritis and immunity as the key words was carried out according to the identification results to clarify the active ingredients of L. rotata in the treatment of RA, so as to speculate the pharmacological effects of aerial parts and roots based on the distribution of active components. A total of 16 potential markers were selected and identified to differentiate two parts. Among them, 8 characteristic flavonoids with similar skeletons were unique in aerial parts, while the other 8 components, including 2 iridoid glycosides and 6 phenylethanoid glycosides, were detected in both aerial parts and roots, but with differentiate contents. Among the predicted 6 active components, there were 5 flavonoids, of which 3 (namely luteolin, apigenin and 2″-acetylastragalin) were still differential metabolites and mainly distributed in the aerial parts. The results revealed that certain flavonoids as potential markers made a distinction between aerial part and root of L. rotata, and were the main active components against RA, which provided a theoretical basis for the aerial parts to replace the whole herbs, and laid a material foundation for further pharmacological research.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.arabjc.2022.103740
- OA Status
- gold
- Cited By
- 4
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210336094
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https://openalex.org/W4210336094Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.arabjc.2022.103740Digital Object Identifier
- Title
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Comparative investigation of aerial part and root in Lamiophlomis rotata using UPLC-Q-Orbitrap-MS coupled with chemometricsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-29Full publication date if available
- Authors
-
Tong Li, Jia Li, Ruijiao Du, Chengjuan Liu, Shengjie Huang, Heshui Yu, Lifeng Han, Xiaopeng Chen, Yuefei Wang, Miaomiao JiangList of authors in order
- Landing page
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https://doi.org/10.1016/j.arabjc.2022.103740Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.arabjc.2022.103740Direct OA link when available
- Concepts
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Chemistry, Traditional medicine, Botany, Biology, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
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2025: 1, 2024: 1, 2022: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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