Comparative Proteomic Analysis of Extracellular Vesicles from Donkey Colostrum and Mature Milk Article Swipe
Simonetta Caira
,
Sandra Buratta
,
Silvia Vincenzetti
,
Raffaella Latella
,
Matteo Seccaroni
,
Sabrina De Pascale
,
Cristina Federici
,
Luana Lugini
,
Stefano Giovagnoli
,
Anna Maria Salzano
,
Carla Emiliani
,
Andrea Scaloni
,
Elisabetta Chiaradia
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/metabo15090619
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/metabo15090619
Background/Objectives: Donkey milk (DM) has been considered a valuable alternative to human and bovine counterparts as well as to infant formulas. Milk extracellular vesicles (EVs) have been proposed to influence key biological processes. The purpose of this study is to provide a comprehensive characterization of the protein composition of extracellular vesicles (EVs) by extending quantitative proteomic comparisons to EVs derived from donkey colostrum (DC) and mature donkey milk (MDM). Methods: The EVs were isolated from DC and MDM samples, characterized, and subjected to proteomic analysis using the tandem mass tag-based quantitative approach. Results: In addition to typical milk proteins and EV markers, EVs from DC and MDM both contain components associated with the immune system, immune response, or promoting tissue repair, and assisting with communication between the infant and their environment. The EVs from DC were enriched in proteins associated with protein turnover, specific defense functions, and regenerative processes. Conclusions: Overall, the results can contribute to the broader characterization of the overall protein composition of DC and MDM and might help to predict the beneficial effects of the corresponding EVs on various mammalian cells. They may also provide valuable insights for the development of novel DM-based products for food, pharmaceutical, and biotechnological applications.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/metabo15090619
- https://www.mdpi.com/2218-1989/15/9/619/pdf?version=1758196130
- OA Status
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- References
- 74
- OpenAlex ID
- https://openalex.org/W4414329056
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https://doi.org/10.3390/metabo15090619Digital Object Identifier
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Comparative Proteomic Analysis of Extracellular Vesicles from Donkey Colostrum and Mature MilkWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-09-18Full publication date if available
- Authors
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Simonetta Caira, Sandra Buratta, Silvia Vincenzetti, Raffaella Latella, Matteo Seccaroni, Sabrina De Pascale, Cristina Federici, Luana Lugini, Stefano Giovagnoli, Anna Maria Salzano, Carla Emiliani, Andrea Scaloni, Elisabetta ChiaradiaList of authors in order
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https://doi.org/10.3390/metabo15090619Publisher landing page
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https://www.mdpi.com/2218-1989/15/9/619/pdf?version=1758196130Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2218-1989/15/9/619/pdf?version=1758196130Direct OA link when available
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