Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues Article Swipe
Severin Ruoss
,
Chanond A. Nasamran
,
Scott T. Ball
,
Jeffrey Chen
,
Kenneth Halter
,
Kelly Bruno
,
Thomas Whisenant
,
Jesal N. Parekh
,
Shanelle N. Dorn
,
Mary C. Esparza
,
Shannon N. Bremner
,
Kathleen M. Fisch
,
Adam J. Engler
,
Samuel R. Ward
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1126/sciadv.adn2831
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1126/sciadv.adn2831
Bone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction (ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the general population and elite athletes. Both tissues have been used interchangeably clinically even though their detailed composition, heterogeneity, and mechanisms of action have neither been rigorously inventoried nor compared. This lack of information has prevented investigations into ideal dosages and has facilitated anecdata and misinformation. Here, we analyzed single-cell transcriptomes, proteomes, and flow cytometry profiles from paired clinical-grade BMAC and ADSVF. This comparative transcriptional atlas challenges the prevalent notion that there is one therapeutic cell type present in both tissues. We also provide data of surface markers that may enable isolation and investigation of cell (sub)populations. Furthermore, the proteome atlas highlights intertissue and interpatient heterogeneity of injected proteins with potentially regenerative or immunomodulatory capacities. An interactive webtool is available online.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1126/sciadv.adn2831
- OA Status
- gold
- Cited By
- 4
- References
- 139
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400578722
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4400578722Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1126/sciadv.adn2831Digital Object Identifier
- Title
-
Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissuesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-07-12Full publication date if available
- Authors
-
Severin Ruoss, Chanond A. Nasamran, Scott T. Ball, Jeffrey Chen, Kenneth Halter, Kelly Bruno, Thomas Whisenant, Jesal N. Parekh, Shanelle N. Dorn, Mary C. Esparza, Shannon N. Bremner, Kathleen M. Fisch, Adam J. Engler, Samuel R. WardList of authors in order
- Landing page
-
https://doi.org/10.1126/sciadv.adn2831Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1126/sciadv.adn2831Direct OA link when available
- Concepts
-
Mesenchymal stem cell, Stromal vascular fraction, Proteome, Population, Biology, Cell, Proteomics, Computational biology, Flow cytometry, Cell therapy, Cell type, Bioinformatics, Stem cell, Stromal cell, Medicine, Immunology, Cancer research, Cell biology, Genetics, Environmental health, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
139Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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