Comparative structural analysis provides new insights into the function of R2‐like ligand‐binding oxidase Article Swipe
Riccardo Diamanti
,
Vivek Srinivas
,
Annika Johansson
,
Anders Nordström
,
Julia J. Griese
,
Hugo Lebrette
,
Martin Högbom
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/1873-3468.14319
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/1873-3468.14319
R2‐like ligand‐binding oxidase (R2lox) is a ferritin‐like protein that harbours a heterodinuclear manganese–iron active site. Although R2lox function is yet to be established, the enzyme binds a fatty acid ligand coordinating the metal centre and catalyses the formation of a tyrosine–valine ether cross‐link in the protein scaffold upon O 2 activation. Here, we characterized the ligands copurified with R2lox by mass spectrometry‐based metabolomics. Moreover, we present the crystal structures of two new homologs of R2lox, from Saccharopolyspora erythraea and Sulfolobus acidocaldarius, at 1.38 Å and 2.26 Å resolution, respectively, providing the highest resolution structure for R2lox, as well as new insights into putative mechanisms regulating the function of the enzyme.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/1873-3468.14319
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14319
- OA Status
- bronze
- Cited By
- 4
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4212997787
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4212997787Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/1873-3468.14319Digital Object Identifier
- Title
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Comparative structural analysis provides new insights into the function of R2‐like ligand‐binding oxidaseWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-02-17Full publication date if available
- Authors
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Riccardo Diamanti, Vivek Srinivas, Annika Johansson, Anders Nordström, Julia J. Griese, Hugo Lebrette, Martin HögbomList of authors in order
- Landing page
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https://doi.org/10.1002/1873-3468.14319Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14319Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.14319Direct OA link when available
- Concepts
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Chemistry, Ligand (biochemistry), Function (biology), Computational biology, Biochemistry, Biology, Cell biology, ReceptorTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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45Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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