Comparing the Fate of Brain Metastatic Breast Cancer Cells in Different Immune Compromised Mice with Cellular Magnetic Resonance Imaging Article Swipe
Natasha N. Knier
,
Amanda M. Hamilton
,
Paula J. Foster
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.02.18.954693
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.02.18.954693
Metastasis is the leading cause of mortality in breast cancer patients, with brain metastases becoming increasingly prevalent. Studying this disease is challenging due to the limited experimental models and methods available. Here, we used iron-based cellular MRI to track the fate of a mammary carcinoma cell line (MDA-MB-231-BR) in vivo to characterize the growth of brain metastases in the nude and severely immune-compromised NOD/SCID/ILIIrg−/− (NSG) mouse. Nude and NSG mice received injections of iron-labeled MDA-MB-231-BR cells. Images were acquired with a 3T MR system and assessed for signal voids and metastases. The percentage of signal voids and the number and volume of metastases were quantified. Ex vivo imaging of the liver, histology, and immunofluorescence labeling was performed. On day 0, iron-labeled cells were visualized as signal voids throughout the brain. The percentage of voids decreased significantly between day 0 and endpoint. At endpoint, there was no difference in the number of brain metastases or tumour burden in NSG mice compared to nudes. Tumour volumes in nude mice were significantly larger than in NSG mice. Body images indicated that the NSG mice had metastases in the liver, lungs, and lymph nodes. Characterization of the NSG and nude mouse is necessary to study breast cancer brain metastasis in vivo . Here, we show that the 231BR cell line grew differently in NSG mice compared to nude mice. This work demonstrates the role that imaging can play toward credentialing these models that cannot be done with other in vitro or histopathologic methods alone.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.02.18.954693
- https://www.biorxiv.org/content/biorxiv/early/2020/02/19/2020.02.18.954693.full.pdf
- OA Status
- green
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3008968951
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3008968951Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.02.18.954693Digital Object Identifier
- Title
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Comparing the Fate of Brain Metastatic Breast Cancer Cells in Different Immune Compromised Mice with Cellular Magnetic Resonance ImagingWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-02-19Full publication date if available
- Authors
-
Natasha N. Knier, Amanda M. Hamilton, Paula J. FosterList of authors in order
- Landing page
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https://doi.org/10.1101/2020.02.18.954693Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/02/19/2020.02.18.954693.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2020/02/19/2020.02.18.954693.full.pdfDirect OA link when available
- Concepts
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Breast cancer, Brain metastasis, In vivo, Pathology, Magnetic resonance imaging, Metastasis, Cancer, Medicine, Immune system, Cancer research, Preclinical imaging, Nude mouse, Biology, Immunology, Internal medicine, Radiology, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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49Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W4254121386, https://openalex.org/W2533301708, https://openalex.org/W2016908822, https://openalex.org/W2186000591, https://openalex.org/W185134482, https://openalex.org/W1968442275, https://openalex.org/W2560406314, https://openalex.org/W2007897263, https://openalex.org/W2014119944, https://openalex.org/W2039437097, https://openalex.org/W2169855644, https://openalex.org/W2126799977, https://openalex.org/W1559451312, https://openalex.org/W2291663432, https://openalex.org/W2026987067, https://openalex.org/W2521953092, https://openalex.org/W2168102484, https://openalex.org/W2249369834, https://openalex.org/W2772931741, https://openalex.org/W2742005115, https://openalex.org/W2015187541, https://openalex.org/W2001679453, https://openalex.org/W2564066883, https://openalex.org/W2113506041, https://openalex.org/W2754871120, https://openalex.org/W2774944351, https://openalex.org/W2765527092, https://openalex.org/W1971423558, https://openalex.org/W2150902592, https://openalex.org/W2162511259, https://openalex.org/W1986621423, https://openalex.org/W1906623925, https://openalex.org/W2526160173, https://openalex.org/W2118473182, https://openalex.org/W2550697219, https://openalex.org/W2028257330, https://openalex.org/W2044333992, https://openalex.org/W2537010419, https://openalex.org/W1937925273, https://openalex.org/W2591420118, https://openalex.org/W1494987922, https://openalex.org/W2094383506, https://openalex.org/W2104666893, https://openalex.org/W2522708935, https://openalex.org/W2150429839, https://openalex.org/W2296981264, https://openalex.org/W4206509728, https://openalex.org/W2444014736, https://openalex.org/W2134433047 |
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