Comparing Treatment Approaches for Older Adults with Treatment-Resistant Depression -- The OPTIMUM Study Article Swipe

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Depression (economics) Treatment-resistant depression Medicine Psychology Psychiatry Major depressive disorder Cognition Economics Macroeconomics

Eric J. Lenze , Torie Gettinger , Emily Lenard , Jordan F. Karp , Benoit H. Mulsant , Steven P. Roose , Helen Lavretsky , Charles F. Reynolds , Daniel M. Blumberger , Patrick J. Brown , Flor de Abril Cameron , Pilar Cristancho , Alicia Dawdani , Alastair J. Flint , Marie Anne Gebara , Megan Hamm , Philip Miller , Ginger E. Nicol , Hanadi Ajam Oughli , Vy Pham , Bruce L. Rollman , Rachel Wasilko , Lei Yang ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.25302/10.2023.trd.151133321 · OA: W4387581465

How can people use the results?Older patients and their doctors can use these results when considering ways to treat treatment-resistant depression.To learn more about this project, visit www.pcori.org/Lenze481.PCORI identified treatment-resistant depression as an important research topic.Patients, clinicians, and others wanted to learn: For patients whose depression has not gotten better after using two types of antidepressants, is it better to add another treatment or switch to a new one?To help answer this question, PCORI launched an initiative in 2015 on Management Strategies for Treatment-Resistant Depression.The initiative funded this research project and others.