Comparison of 2 Doses for ACTH Stimulation Testing in Dogs Suspected of or Treated for Hyperadrenocorticism Article Swipe
Cara Aldridge
,
Ellen N. Behrend
,
R.J. Kemppainen
,
Tekla M. Lee‐Fowler
,
Linda G. Martin
,
Cynthia R. Ward
,
David S. Bruyette
,
Jasdeep Pannu
,
Philippe Gaillard
,
H.P. Lee
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1111/jvim.14528
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1111/jvim.14528
Background Lowering the cosyntropin dose needed for ACTH stimulation would make the test more economical. Objectives To compare the cortisol response to 1 and 5 μg/kg cosyntropin IV in dogs being screened for hyperadrenocorticism ( HAC ) and in dogs receiving trilostane or mitotane for pituitary‐dependent HAC . Animals Healthy dogs (n = 10); client‐owned dogs suspected of having HAC (n = 39) or being treated for pituitary‐dependent HAC with mitotane (n = 12) or trilostane (n = 15). Procedures In this prospective study, healthy dogs had consecutive ACTH stimulation tests to ensure 2 tests could be performed in sequence. For the first test, cosyntropin (1 μg/kg IV ) was administered; the second test was initiated 4 hours after the start of the first (5 μg/kg cosyntropin IV ). Dogs suspected of having HAC or being treated with mitotane were tested as the healthy dogs. Dogs receiving trilostane treatment were tested on consecutive days at the same time post pill using the low dose on day 1. Results In dogs being treated with mitotane or trilostane, the 2 doses were pharmacodynamically equivalent (90% confidence interval, 85.1–108.2%; P = 0.014). However, in dogs suspected of having HAC , the doses were not pharmacodynamically equivalent (90% confidence interval, 73.2–92.8%; P = 0.37); furthermore, in 23% of the dogs, clinical interpretation of test results was different between the doses. Conclusions and Clinical Relevance For dogs suspected of having HAC , 5 μg/kg cosyntropin IV is still recommended for ACTH stimulation testing. For dogs receiving mitotane or trilostane treatment, a dose of 1 μg/kg cosyntropin IV can be used.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/jvim.14528
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.14528
- OA Status
- gold
- Cited By
- 17
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2500906381
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2500906381Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/jvim.14528Digital Object Identifier
- Title
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Comparison of 2 Doses for ACTH Stimulation Testing in Dogs Suspected of or Treated for HyperadrenocorticismWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
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2016-07-18Full publication date if available
- Authors
-
Cara Aldridge, Ellen N. Behrend, R.J. Kemppainen, Tekla M. Lee‐Fowler, Linda G. Martin, Cynthia R. Ward, David S. Bruyette, Jasdeep Pannu, Philippe Gaillard, H.P. LeeList of authors in order
- Landing page
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https://doi.org/10.1111/jvim.14528Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.14528Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.14528Direct OA link when available
- Concepts
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Medicine, Stimulation, Adrenocorticotropic hormone, Internal medicine, HormoneTop concepts (fields/topics) attached by OpenAlex
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17Total citation count in OpenAlex
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2024: 2, 2023: 4, 2022: 2, 2021: 1, 2019: 2Per-year citation counts (last 5 years)
- References (count)
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18Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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