Comparison of Automatic Segmentation and Preprocessing Approaches for Dynamic Total-Body 3D Pet Images with Different Pet Tracers Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.1007/s10278-025-01540-4
Segmentation is a routine step in PET image analysis, and few automatic tools have been developed for it. However, excluding supervised methods with their own limitations, they are typically designed for older, small images and the implementations are no longer publicly available. Here, we test if different commonly used building blocks of the automatic methods work with large modern total-body PET images. Dynamic total-body images from five different datasets are used for evaluation purposes, and the tested algorithms cover wide range of different preprocessing approaches and unsupervised segmentation methods. The validation is done by comparing the obtained segments to manually drawn ones using Jaccard index, Dice score, precision, and recall as measures of match. Out of the 17 considered segmentation methods, only 6 were computationally usable and provided enough segments for the needs of this study. Among these six feasible methods, hierarchical clustering and HDBSCAN had systematically the lowest Jaccard indices with the manual segmentations, whereas both GMM and k -means had median Jaccards of 0.58 over different organ segments and data sets. GMM outperformed k -means in human data, but with rat images, the two methods had equally good performance k -means having slightly stronger precision and GMM recall. We conclude that most of the commonly used unsupervised segmentation methods are computationally infeasible with the modern PET images, classical clustering algorithms k -means and especially Gaussian mixture model being the most promising candidates for further method development. Even though preprocessing, particularly denoising, improved the results, small organs remained difficult to segment.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s10278-025-01540-4
- https://link.springer.com/content/pdf/10.1007/s10278-025-01540-4.pdf
- OA Status
- hybrid
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410794800
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410794800Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s10278-025-01540-4Digital Object Identifier
- Title
-
Comparison of Automatic Segmentation and Preprocessing Approaches for Dynamic Total-Body 3D Pet Images with Different Pet TracersWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-27Full publication date if available
- Authors
-
Maria K. Jaakkola, M. Pineda, Rafael Díaz, Maria Rantala, Anna Jalo, Henri Kärpijoki, Teemu Saari, Teemu Maaniitty, Thomas H. Keller, Heli Louhi, Saara Wahlroos, Merja Haaparanta‐Solin, Olof Solin, Jaakko Hentilä, Jatta S. Helin, Tuuli A. Nissinen, Olli Eskola, Johan Rajander, Juhani Knuuti, Kirsi A. Virtanen, Jarna C. Hannukainen, Francisco R. Lopez‐Picon, Riku KlénList of authors in order
- Landing page
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https://doi.org/10.1007/s10278-025-01540-4Publisher landing page
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https://link.springer.com/content/pdf/10.1007/s10278-025-01540-4.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
- OA URL
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https://link.springer.com/content/pdf/10.1007/s10278-025-01540-4.pdfDirect OA link when available
- Concepts
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Jaccard index, Preprocessor, Segmentation, Computer science, Artificial intelligence, Pattern recognition (psychology), Cluster analysis, Hierarchical clustering, Image segmentation, Mixture modelTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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44Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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