Comparison of Radio- and Phototoxicity in Association with an Enhancing Effect of the Photosensitizers Psoralen, Trioxsalen and Ortho-Iodo-Hoechst33258 on FaDu, PC-3, 4T1 and B16-F10 Cells Article Swipe
Katja Tietze
,
Florian Brandt
,
K. Wetzig
,
Lisa Hübinger
,
Marc Pretze
,
Ralph A. Bundschuh
,
Jörg Kotzerke
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines13010073
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines13010073
Background: Energy delivered at different wavelengths causes different types of damage to DNA. Methods: PC-3, FaDu, 4T1 and B16-F10 cells were irradiated with different wavelengths of ultraviolet light (UVA/UVC) and ionizing radiation (X-ray). Furthermore, different photosensitizers (ortho-iodo-Hoechst33258/psoralen/trioxsalen) were tested for their amplifying effect. Survival fraction and damage analysis using the γH2A.X assay (double-strand breaks) and the ELISA assay (cyclobutane pyrimidine dimers) were compared. Results: The PC-3 cells were found to be the most sensitive cells to the treatment strategies used. FaDu and PC-3 showed a strong sensitivity to UVA. Analysis of the damage showed that the cell lines exhibited different sensitivities. Conclusions: Thus, an enhancing effect of photosensitizers (PS) in combination with UVA could be demonstrated in some cases. However, this is cell- and dose-dependent.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines13010073
- https://www.mdpi.com/2227-9059/13/1/73/pdf?version=1735638239
- OA Status
- gold
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405974106
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405974106Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines13010073Digital Object Identifier
- Title
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Comparison of Radio- and Phototoxicity in Association with an Enhancing Effect of the Photosensitizers Psoralen, Trioxsalen and Ortho-Iodo-Hoechst33258 on FaDu, PC-3, 4T1 and B16-F10 CellsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-12-31Full publication date if available
- Authors
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Katja Tietze, Florian Brandt, K. Wetzig, Lisa Hübinger, Marc Pretze, Ralph A. Bundschuh, Jörg KotzerkeList of authors in order
- Landing page
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https://doi.org/10.3390/biomedicines13010073Publisher landing page
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https://www.mdpi.com/2227-9059/13/1/73/pdf?version=1735638239Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2227-9059/13/1/73/pdf?version=1735638239Direct OA link when available
- Concepts
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Psoralen, Phototoxicity, Pyrimidine dimer, Chemistry, DNA damage, Molecular biology, Ultraviolet, DNA, Irradiation, Ionizing radiation, Photochemistry, Biophysics, In vitro, Biochemistry, Biology, Materials science, Physics, Optoelectronics, Nuclear physicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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